{"id":3337,"date":"2021-11-12T12:50:18","date_gmt":"2021-11-12T17:50:18","guid":{"rendered":"https:\/\/abudinen.com\/blog\/?p=3337"},"modified":"2021-11-12T12:50:54","modified_gmt":"2021-11-12T17:50:54","slug":"adjuvant","status":"publish","type":"post","link":"https:\/\/abudinen.com\/blog\/2021\/11\/12\/adjuvant\/","title":{"rendered":"Adjuvant"},"content":{"rendered":"\nMicrobes and Infection Volume 22, Issue 9, October 2020, Pages 405-406\n\n\n\nCommentaryOut of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19\n\n\n\nAuthor links open overlay panelJeremia M.CoishAdam J.MacNeilDepartment of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada\n\n\n\nReceived 8 June 2020, Accepted 18 June 2020, Available online 24 June 2020.\n\n\n\nAntibody-dependent enhancement (ADE) of SARS-CoV-2 infection has recently emerged as one hypothesis to explain the severe clinical manifestations associated with COVID-19 [[1], [2], [3], [4]]. Simply put, ADE is an immunological phenomenon whereby a previous immune response to a virus can render an individual more susceptible to a subsequent analogous infection [5]\n\n\n\n\n\n\n\nMacNeil\u2019s PhD student, Jeremia Coish, says one rare complication to look out for is antibody-dependent enhancement (ADE), a paradoxical immune phenomenon typically associated with dengue hemorrhagic fever. \n\n\n\nAntibody-Dependent Enhancement of Infection and the Pathogenesis of Viral Disease\n\n\n\nDavid M. MorensClinical Infectious Diseases, Volume 19, Issue 3, September 1994, Pages 500\u2013512,  September 1994 \n\n\n\nOut of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19\n\n\n\nJeremia M. Coish and Adam J. MacNeil [...x]<\/span>
Additional article information<\/p>\n\n\n\n

Abstract<\/strong> Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae<\/em>. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust. <\/p>\n\n\n\n

02\/11\/21\u2022BIG PHARMA \u203a VIEWS<\/p>\n\n\n\n

Scientists Warn of Potential COVID Vaccine-Related \u2018Ticking Time Bomb\u2019<\/h2>\n\n\n\n

Studies suggest that COVID vaccines may trigger antibody-dependent enhancement in some people, a condition that could cause them to develop more severe symptoms when exposed to the wild virus than if they hadn\u2019t been vaccinated.By <\/strong>Rob Verkerk Ph.D.<\/strong><\/p>\n\n\n\n

Careful readers of Halstead and Katzelnick\u2019s paper will note that while the authors largely dismiss the ADE risk, they very clearly identify a risk of vaccine hypersensitivity (or VAH), a closely related immunological hyper-reaction that was first identified in the late 1960s when children developed atypical measles following measles vaccination.<\/p>\n\n\n\n

Many who\u2019ve used the paper to dismiss ADE risks may only have read the title and abstract and not picked up that Katzelnick and Halstead dismiss only intrinsic ADE or iADE (i.e. the risk of disease enhancement on re-infection in the absence of vaccination).<\/p>\n\n\n\n

They also may not have read the sombre advisory in the paper\u2019s last sentence: \u201cGiven the magnitude of the repertoire of COVID-19 problems and the need for an effective vaccine, the full force of worldwide investigative resources should be directed at unravelling the pathogenesis of VAH.\u201d<\/p>\n\n\n\n

<\/p>\n\n\n\n

Robert F. Kennedy Jr.<\/p>\n\n\n\n

The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health (Children\u2019s Health Defense)<\/h2>\n\n\n\n

5.0 de 5 estrellas<\/em> (1)Opiniones#1 m\u00e1s vendido<\/em> en Inmunolog\u00eda <\/p>\n\n\n\n

11\/05\/21\u2022COVID \u203a NEWS<\/p>\n\n\n\n

We\u2019re Not in a \u2018Pandemic of the Unvaccinated,\u2019 Peter Doshi Explains During COVID Panel<\/h2>\n\n\n\n

Peter Doshi, a senior editor at The BMJ, and Retsef Levi, a professor at the Massachusetts Institute of Technology, told a panel of experts the COVID vaccines\u2019 trial data doesn\u2019t support the narrative that the vaccines are safe and effective.By Jeremy Loffredo<\/strong> <\/p>\n\n\n\n

Senior NIH expert pushes back on growing vaccine mandates<\/h2>\n\n\n\n

Matthew Memoli favors vaccinations in vulnerable populations but argues population level vaccination could hinder the development of a natural, robust immunity gained through infection.ByAdam Barnes | Nov. 8, 2021<\/em> <\/p>\n\n\n\n

Esto es lo que NO se nos dice sobre las vacunas y el autismo:<\/p>\n\n\n\n

“Los anticuerpos de la triple v\u00edrica son significativamente m\u00e1s altos en los ni\u00f1os autistas en comparaci\u00f3n con los ni\u00f1os normales, lo que apoya un papel de la triple v\u00edrica en el autismo”.<\/p>\n\n\n\n

Immunological findings in autism<\/h2>\n\n\n\n

Hari Har Parshad Cohly et al. Int Rev Neurobiol. 2005. <\/p>\n\n\n\n

Abstract<\/strong> The immunopathogenesis of autism is presented schematically in Fig. 1. Two main immune dysfunctions in autism are immune regulation involving pro-inflammatory cytokines and autoimmunity. Mercury and an infectious agent like the measles virus are currently two main candidate environmental triggers for immune dysfunction in autism. Genetically immune dysfunction in autism involves the MHC region, as this is an immunologic gene cluster whose gene products are Class I, II, and III molecules. Class I and II molecules are associated with antigen presentation. The antigen in virus infection initiated by the virus particle itself while the cytokine production and inflammatory mediators are due to the response to the putative antigen in question. The cell-mediated immunity is impaired as evidenced by low numbers of CD4 cells and a concomitant T-cell polarity with an imbalance of Th1\/Th2 subsets toward Th2. Impaired humoral immunity on the other hand is evidenced by decreased IgA causing poor gut protection. Studies showing elevated brain specific antibodies in autism support an autoimmune mechanism. Viruses may initiate the process but the subsequent activation of cytokines is the damaging factor associated with autism. Virus specific antibodies associated with measles virus have been demonstrated in autistic subjects. Environmental exposure to mercury is believed to harm human health possibly through modulation of immune homeostasis. A mercury link with the immune system has been postulated due to the involvement of postnatal exposure to thimerosal, a preservative added in the MMR vaccines. The occupational hazard exposure to mercury causes edema in astrocytes and, at the molecular level, the CD95\/Fas apoptotic signaling pathway is disrupted by Hg2+. Inflammatory mediators in autism usually involve activation of astrocytes and microglial cells. Proinflammatory chemokines (MCP-1 and TARC), and an anti-inflammatory and modulatory cytokine, TGF-beta1, are consistently elevated in autistic brains. In measles virus infection, it has been postulated that there is immune suppression by inhibiting T-cell proliferation and maturation and downregulation MHC class II expression. Cytokine alteration of TNF-alpha is increased in autistic populations. Toll-like-receptors are also involved in autistic development. High NO levels are associated with autism. Maternal antibodies may trigger autism as a mechanism of autoimmunity. MMR vaccination may increase risk for autism via an autoimmune mechanism in autism. MMR antibodies are significantly higher in autistic children as compared to normal children, supporting a role of MMR in autism. Autoantibodies (IgG isotype) to neuron-axon filament protein (NAFP) and glial fibrillary acidic protein (GFAP) are significantly increased in autistic patients (Singh et al., 1997). Increase in Th2 may explain the increased autoimmunity, such as the findings of antibodies to MBP and neuronal axonal filaments in the brain. There is further evidence that there are other participants in the autoimmune phenomenon. (Kozlovskaia et al., 2000). The possibility of its involvement in autism cannot be ruled out. Further investigations at immunological, cellular, molecular, and genetic levels will allow researchers to continue to unravel the immunopathogenic mechanisms’ associated with autistic processes in the developing brain. This may open up new avenues for prevention and\/or cure of this devastating neurodevelopmental disorder.<\/p>\n\n\n\n

“Nuestros resultados proporcionan una fuerte evidencia que apoya un v\u00ednculo entre el autismo y el aluminio en las vacunas\u2026” ~ Entrop\u00eda 2012<\/p>\n\n\n\n

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure \u2020<\/sup><\/h2>\n\n\n\n

by Stephanie Seneff<\/strong> 1,*<\/sup>,Robert M. Davidson<\/strong> 2<\/sup> andJingjing Liu<\/strong> 1<\/sup> <\/p>\n\n\n\n

“En conclusi\u00f3n, la persistencia a largo plazo del hidr\u00f3xido de aluminio derivado de las vacunas dentro del cuerpo evaluado por la MMF se asocia con la disfunci\u00f3n cognitiva”<\/p>\n\n\n\n

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction<\/h2>\n\n\n\n

Maryline Couette et al. J Inorg Biochem. 2009 Nov. <\/p>\n\n\n\n

*** “Nuestros resultados muestran que los ni\u00f1os de los pa\u00edses con mayor prevalencia del Trastorno del Espectro Autista parecen tener la mayor exposici\u00f3n al aluminio de las vacunas.” ~ Journal of Inorganic Biochemistry<\/p>\n\n\n\n

<\/p>\n\n\n\n

Efectos t\u00f3xicos del aluminio como adyuvante de las vacunas “Todos estos hallazgos implican plausiblemente a los adyuvantes de Al en las vacunas pedi\u00e1tricas como factores causales del aumento de las tasas de trastornos del espectro autista en los pa\u00edses donde se administran universalmente m\u00faltiples dosis.”<\/p>\n\n\n\n

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease<\/h2>\n\n\n\n

Christopher A. Shaw, Stephanie Seneff, […], and Robert M. Davidson <\/p>\n\n\n\n

El aluminio en las vacunas infantiles no es seguro- Journal of American Physicians and Surgeons Volumen 21 N\u00famero 4 Invierno 2016<\/p>\n\n\n\n

<\/p>\n\n\n\n

Biopersistencia y translocaci\u00f3n cerebral de los adyuvantes de aluminio de las vacunas.<\/p>\n\n\n\n

Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines<\/h2>\n\n\n\n

Romain Kroum Gherardi, Housam Eidi, […], and Josette Cadusseau <\/p>\n\n\n\n

El CDC s\u00ed encontr\u00f3 una relaci\u00f3n entre la triple v\u00edrica y el autismo en un estudio de 2001, pero orden\u00f3 a sus cient\u00edficos que destruyeran los datos. El Dr. William Thompson se convirti\u00f3 en denunciante y entreg\u00f3 sus copias originales del estudio al congreso.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Master Manipulator: The Explosive True Story of Fraud, Malversaci\u00f3n, and Government Betrayal at the CDC. Se trata del tipo que hizo el estudio que “probaba” que la triple v\u00edrica no causaba autismo, pero era un fraude y malvers\u00f3 dinero de los fondos del estudio.<\/p>\n\n\n\n

<\/p>\n\n\n\n

REVIEW “Por lo tanto, los ni\u00f1os autistas tienen una respuesta hiperinmune al virus del sarampi\u00f3n, que en ausencia de un tipo salvaje de infecci\u00f3n de sarampi\u00f3n podr\u00eda ser un signo de una reacci\u00f3n inmune anormal a la cepa de la vacuna o la reactivaci\u00f3n del virus.”<\/p>\n\n\n\n

“En otras palabras, casi todos los ni\u00f1os seguidos en el estudio que desarrollaron autismo (88%) ten\u00edan autismo regresivo. Eso significa que NO nacieron con \u00e9l, sino que experimentaron un declive significativo de sus funciones despu\u00e9s de un factor de estr\u00e9s ambiental.”<\/p>\n\n\n\n

Onset patterns in autism: Variation across informants, methods, and timing<\/h2>\n\n\n\n

Sally Ozonoff et al. Autism Res. 2018 May.Free PMC article <\/p>\n\n\n\n

Abstract<\/strong> While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under-reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n = 147) and without a family history of ASD (n = 83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788-797. \u00a9 2018 International Society for Autism Research, Wiley Periodicals, Inc.<\/p>\n\n\n\n

Lay summary: <\/strong>This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use.<\/p>\n\n\n\n

Keywords: <\/strong>early signs; infants; regression.<\/p>\n\n\n\n

\u00a9 2018 International Society for Autism Research, Wiley Periodicals, Inc.<\/p>\n\n\n\n

\u00bfQu\u00e9 es el autismo regresivo y por qu\u00e9 se produce? \u00bfEs la consecuencia de una disfunci\u00f3n multisist\u00e9mica que afecta a la eliminaci\u00f3n de metales pesados y a la capacidad de regular la temperatura neuronal?<\/p>\n\n\n\n

What is regressive autism and why does it occur? Is it the consequence of multi-systemic dysfunction affecting the elimination of heavy metals and the ability to regulate neural temperature?<\/h2>\n\n\n\n

Graham E. Ewing <\/p>\n\n\n\n

Concentraciones de metales t\u00f3xicos en el cabello y gravedad del trastorno del espectro autista en ni\u00f1os peque\u00f1os<\/p>\n\n\n\n

Hair Toxic Metal Concentrations and Autism Spectrum Disorder Severity in Young Children<\/h2>\n\n\n\n

David A. Geier, Janet K. Kern, […], and Mark R. Geier<\/p>\n\n\n\n

Statistical analysis<\/strong> [S]imilarly, investigators described that Hg is widespread and persistent in the environment [29,30,31]. Hg is a ubiquitous source of danger in fish, drugs, fungicides\/herbicides, dental fillings, thermometers, vaccines, and many other products\/food stuffs. Elevated Hg concentrations may remain in the brain from several years to decades following exposure.<\/p>\n\n\n\n

“El aluminio en forma de adyuvante conlleva el riesgo de autoinmunidad, inflamaci\u00f3n cerebral a largo plazo, complicaciones neurol\u00f3gicas asociadas y tiene profundas y amplias consecuencias adversas para la salud”. Current Medicinal Chemistry vol. 18 n\u00famero 17 junio 2011 pp 263<\/p>\n\n\n\n

Aluminum vaccine adjuvants: are they safe?<\/h2>\n\n\n\n

L Tomljenovic et al. Curr Med Chem. 2011. <\/p>\n\n\n\n

Abstract<\/strong> Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.<\/p>\n\n\n\n

Metales pesados y autismo.<\/p>\n\n\n\n

<\/p>\n\n\n\n

Un estudio encuentra “algunos de los valores m\u00e1s altos de aluminio en tejido cerebral humano registrados hasta ahora” en cerebros de pacientes autistas. “Hoy en d\u00eda, los beb\u00e9s reciben dosis m\u00faltiples sin precedentes de vacunas con adyuvantes de aluminio”.<\/p>\n\n\n\n

Study Finds “Some of the Highest Values for Aluminium in Human Brain Tissue Yet Recorded” in Brains of Autistic Patients<\/h2>\n\n\n\n

POSTED BY CELESTE MCGOVERN ON NOV 28, 2017 5:29:23 PM <\/p>\n\n\n\n

A 15-year-old autistic boy had one tissue sample with levels of aluminum 22 times higher than those found in healthy individuals. Researchers suggest that childhood vaccines are a potential source of the toxic metal.<\/strong><\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

Microbes and Infection Volume 22, Issue 9, October 2020, Pages 405-406 CommentaryOut of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19 Author links open overlay panelJeremia M.CoishAdam J.MacNeilDepartment of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada Received 8 June 2020, Accepted 18 June … Leer m\u00e1s<\/a><\/p>\n\n

\n Sharing is caring<\/span><\/strong> \n <\/i> Share<\/span><\/a>\n <\/i> +1<\/span><\/a>\n <\/i> Tweet<\/span><\/a>\n <\/i> Share<\/span><\/a>\n <\/i> Share<\/span><\/a>\n 2631 words 117 views<\/w>\n <\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3337","post","type-post","status-publish","format-standard","hentry","category-sin-categoria"],"_links":{"self":[{"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/posts\/3337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/comments?post=3337"}],"version-history":[{"count":49,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/posts\/3337\/revisions"}],"predecessor-version":[{"id":3495,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/posts\/3337\/revisions\/3495"}],"wp:attachment":[{"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/media?parent=3337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/categories?post=3337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/abudinen.com\/blog\/wp-json\/wp\/v2\/tags?post=3337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}