{"id":5791,"date":"2021-12-20T15:28:33","date_gmt":"2021-12-20T20:28:33","guid":{"rendered":"https:\/\/abudinen.com\/blog\/?p=5791"},"modified":"2021-12-20T15:30:42","modified_gmt":"2021-12-20T20:30:42","slug":"conciencia-y-neuronas","status":"publish","type":"post","link":"https:\/\/abudinen.com\/blog\/2021\/12\/20\/conciencia-y-neuronas\/","title":{"rendered":"Conciencia y neuronas"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">REVIEW <strong>\u00bfSe manifiesta la conciencia a trav\u00e9s de las neuronas cerebrales? <\/strong>N\u00famero 217 &#8211; Julio-Agosto 2018Cambiar tama\u00f1o:&nbsp;<a href=\"https:\/\/www.dsalud.com\/reportaje\/se-manifiesta-la-conciencia-a-traves-de-las-neuronas-cerebrales\/#\" rel=\"noopener nofollow\">AA+A++<\/a>Tiempo de lectura: 10 minutos https:\/\/www.dsalud.com\/reportaje\/se-manifiesta-la-conciencia-a-traves-de-las-neuronas-cerebrales\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El f\u00edsico, matem\u00e1tico y profesor de la&nbsp;<em>Universidad de Oxford<\/em>&nbsp;Roger Penrose y el m\u00e9dico y profesor de la&nbsp;<em>Universidad de Arizona&nbsp;<\/em>Stuart Hameroff afirman que la consciencia tiene entidad propia y se encuentra o manifiesta a trav\u00e9s de los microt\u00fabulos que conforman el citoesqueleto de las neuronas cerebrales organiz\u00e1ndose cu\u00e1nticamente desde ah\u00ed el ADN y la conexi\u00f3n entre los cuerpos f\u00edsico, energ\u00e9tico y mental. Y aunque la gran mayor\u00eda de los cient\u00edficos ortodoxos se opuso inicialmente a tal teor\u00eda el reciente descubrimiento de vibraciones en los microt\u00fabulos neuronales y experimentos sobre los efectos en ellos de los anest\u00e9sicos ha hecho que muchos se replanteen su posici\u00f3n. Cabe a\u00f1adir que seg\u00fan la bi\u00f3loga espa\u00f1ola Mar\u00eda Jes\u00fas Bl\u00e1zquez los microt\u00fabulos podr\u00edan utilizar el agua organizada contenida en los seres vivos como amplificador de se\u00f1ales, secuencias, energ\u00eda e informaci\u00f3n.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.dsalud.com\/wp-content\/uploads\/2018\/06\/NEURONAS.jpg\" alt=\"\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Estudiando en profundidad los efectos de los anest\u00e9sicos el doctor <strong>Stuart Hameroff <\/strong>descubri\u00f3 que act\u00faan sobre los microt\u00fabulos del citoesqueleto de las neuronas \u00abdesconectando\u00bb a la persona, es decir, induciendo un estado de \u00abinconsciencia\u00bb que impide percibir el dolor. Y posteriormente, en colaboraci\u00f3n con <strong>Roger Penrose,<\/strong> que los microt\u00fabulos conectan los cuerpos f\u00edsico, energ\u00e9tico y mental mediante mecanismos cu\u00e1nticos y de ah\u00ed que err\u00f3neamente la mayor\u00eda de los medios de comunicaci\u00f3n hayan difundido que afirman haber descubierto el \u00abalma\u00bb. Quiz\u00e1s porque en la concepci\u00f3n m\u00e1s materialista se concluye que si hay algo inmaterial en el cuerpo debe ser el alma, concepto que en general se asimila adem\u00e1s al de esp\u00edritu. Y es que en la antig\u00fcedad se postulaba que el hombre se compone de una parte material -el cuerpo f\u00edsico-, una mental -el alma- y una metaf\u00edsica que nos conectar\u00eda con el Creador -el esp\u00edritu- pero <strong>Descartes<\/strong> diluy\u00f3 lo ps\u00edquico y lo metaf\u00edsico y postul\u00f3 que solo habr\u00eda dos manifestaciones: una material -el cuerpo- y una inmaterial -el alma-. Algo que la ciencia materialista asumi\u00f3 acr\u00edticamente sin m\u00e1s dando lugar a que ello se conozca como \u00abciencia cartesiana\u00bb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cabe agregar que dada la confusi\u00f3n existente sobre los t\u00e9rminos <em>consciousness<\/em> y <em>conscience<\/em> -consciencia y conciencia- el profesor Hameroff nos aclarar\u00eda que en sus art\u00edculos \u00e9l se refiere exclusivamente a la consciencia y en el sentido filos\u00f3fico de <em>qualia<\/em>, t\u00e9rmino que define las cualidades sensitivas subjetivas que acompa\u00f1an a nuestros procesos cerebrales y percepciones.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pues bien, Penrose y Hameroff propusieron conjuntamente en los a\u00f1os noventa del pasado siglo XX lo que denominaron <em><a href=\"https:\/\/es.wikipedia.org\/wiki\/Reducci%C3%B3n_objetiva_orquestada\" rel=\"noopener nofollow\">Hip\u00f3tesis de Reducci\u00f3n Objetiva Orquestada (Orch OR)<\/a> \u2013<\/em>que han venido completando y reformulando- seg\u00fan la cual la consciencia obedecer\u00eda a procesos cu\u00e1nticos biol\u00f3gicos sincronizados y organizados que se manifestar\u00edan a trav\u00e9s de los microt\u00fabulos del interior de las neuronas cerebrales regulando asimismo las sinapsis neuronales. Teor\u00eda que acerca el concepto de consciencia a una concepci\u00f3n m\u00e1s bien espiritual. Y es que para la Mec\u00e1nica Cu\u00e1ntica las part\u00edculas que conforman la materia pueden estar en dos lugares simult\u00e1neamente. Siendo posible verlas en una u otra posici\u00f3n solo cuando la probabilidad \u00abcolapsa\u00bb, algo que depende del observador. Fue eso de hecho lo que hizo preguntarse a Penrose qu\u00e9 pasa cuando un conjunto de posibilidades que no puede observarse conscientemente se produce dentro del cerebro porque si lo postulado antes es correcto y nadie puede observarlo nunca se producir\u00eda el colapso que dar\u00eda lugar a una de tales posibilidades. Y su conclusi\u00f3n fue que una de las posibilidades se producir\u00eda igualmente sin observador porque antes o despu\u00e9s una colapsa. Colapso que decidir\u00eda la consciencia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Propuesta que lleva a una nueva pregunta: \u00bfqu\u00e9 -o \u00abqui\u00e9n\u00bb- hay detr\u00e1s de lo material e incluso de la mente? \u00bfUn \u00abcreador\u00bb? Penrose y Hameroff creen que detr\u00e1s hay algo inmaterial -espiritual pues- que se expresar\u00eda a trav\u00e9s de la geometr\u00eda cu\u00e1ntica del espacio-tiempo haciendo que exista una aut\u00e9ntica interconexi\u00f3n cu\u00e1ntica entre todos los seres vivos y el cosmos. Hablar\u00edamos pues de una especie de entidad c\u00f3smica -fruto de toda la informaci\u00f3n y experiencias que le llegar\u00edan transmitidas por las consciencias de todos los seres vivos- con la que estar\u00edamos interconectados a nivel cu\u00e1ntico.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>INVESTIGACIONES QUE AVALAN LA TEOR\u00cdA<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Obviamente tales postulados recibieron enormes cr\u00edticas por quienes integran la comunidad cient\u00edfica m\u00e1s materialista pero 20 a\u00f1os despu\u00e9s diversas investigaciones parecen confirmar su hip\u00f3tesis; al menos en algunos aspectos. Un equipo de cient\u00edficos coordinado por el f\u00edsico bengal\u00ed <em><strong>Anirban Bandyopadhyay<\/strong> descubri\u00f3 de hecho <\/em>vibraciones cu\u00e1nticas <em>en los microt\u00fabulos del interior de las neuronas cerebrales <\/em>contradiciendo a quienes<em> alegaban que el cerebro es \u00abdemasiado c\u00e1lido, h\u00famedo y ruidoso\u00bb para que los sensibles procesos cu\u00e1nticos puedan tener lugar. Lo dieron a conocer en dos art\u00edculos: Multi-level memory-switching properties of a single brain microtubule <\/em>y <em>Atomic water channel controlling remarkable properties of a single brain microtubule: correlating single protein to its supramolecular assembly<\/em>\u00ab. El primero apareci\u00f3 en 2013 en <em>Applied Physics Letters<\/em> y el segundo el mismo a\u00f1o en <em>Biosens Bioelectron<\/em> (los tiene en los siguientes enlaces: <a href=\"https:\/\/aip.scitation.org\/doi\/10.1063\/1.4793995\" rel=\"noopener nofollow\"><em>https:\/\/aip.scitation.org\/doi\/10.1063\/1.4793995<\/em><\/a> y <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23567633\" rel=\"noopener nofollow\"><em>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23567633<\/em><\/a>).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/aip.scitation.org\/\" rel=\"noopener nofollow\">Home&nbsp;<\/a>&gt;&nbsp;<a href=\"https:\/\/aip.scitation.org\/journal\/apl\" rel=\"noopener nofollow\">Applied Physics Letters&nbsp;<\/a>&gt;&nbsp;<a href=\"https:\/\/aip.scitation.org\/toc\/apl\/102\/12\" rel=\"noopener nofollow\">Volume 102, Issue 12&nbsp;<\/a>&gt;&nbsp;10.1063\/1.4793995<a href=\"https:\/\/aip.scitation.org\/doi\/10.1063\/1.4798584\" rel=\"noopener nofollow\">&nbsp;PREV<\/a><a href=\"https:\/\/aip.scitation.org\/doi\/10.1063\/1.4798552\" rel=\"noopener nofollow\">NEXT&nbsp;<\/a>No Access&nbsp;&nbsp;Submitted: 31 October 2012&nbsp;&nbsp;Accepted: 18 February 2013&nbsp;&nbsp;Published Online: 26 March 2013 <strong>Multi-level memory-switching properties of a single brain microtubule<\/strong> Appl. Phys. Lett.&nbsp;<strong>102<\/strong>, 123701 (2013);&nbsp;<a href=\"https:\/\/doi.org\/10.1063\/1.4793995\" rel=\"noopener nofollow\">https:\/\/doi.org\/10.1063\/1.4793995<\/a><a href=\"https:\/\/aip.scitation.org\/author\/Sahu%2C+Satyajit\" rel=\"noopener nofollow\">Satyajit Sahu<\/a><sup>1<\/sup><em>,&nbsp;<\/em><a href=\"https:\/\/aip.scitation.org\/author\/Ghosh%2C+Subrata\" rel=\"noopener nofollow\">Subrata Ghosh<\/a><sup>1<\/sup><em>,&nbsp;<\/em><a href=\"https:\/\/aip.scitation.org\/author\/Hirata%2C+Kazuto\" rel=\"noopener nofollow\">Kazuto Hirata<\/a><sup>2<\/sup><em>,&nbsp;<\/em><a href=\"https:\/\/aip.scitation.org\/author\/Fujita%2C+Daisuke\" rel=\"noopener nofollow\">Daisuke Fujita<\/a><sup>1<\/sup><em>, and&nbsp;<\/em><a href=\"https:\/\/aip.scitation.org\/author\/Bandyopadhyay%2C+Anirban\" rel=\"noopener nofollow\">Anirban Bandyopadhyay<\/a><sup>1,&nbsp;a)<\/sup> ABSTRACT We demonstrate that a single brain-neuron-extracted microtubule is a memory-switching element, whose&nbsp;hysteresis&nbsp;loss is nearly zero. Our study shows how a memory-state forms in the&nbsp;nanowire&nbsp;and how its&nbsp;protein&nbsp;arrangement symmetry is related to the&nbsp;conducting-state&nbsp;written in the device, thus, enabling it to store and process \u223c500 distinct bits, with 2\u2009pA resolution between 1\u2009nA and 1\u2009pA. Its random access memory is an analogue of flash memory switch used in a computer chip. Using&nbsp;scanning tunneling microscope&nbsp;imaging, we demonstrate how single&nbsp;proteins&nbsp;behave inside the&nbsp;nanowire&nbsp;when this 3.5 billion years old&nbsp;nanowire&nbsp;processes memory-bits.Authors acknowledge Eiichiro Watanabe and Daiju Tsuya of Nanotechnology Innovation Station, NIMS Sengen-site Nano-oundry sponsored by Ministry of Science, Education, Culture and Sports (MEXT), Govt. of Japan. The current research work was funded by Asian office of Aerospace R&amp;D, Govt. of USA FA2386-11-1-0001AOARD104173 and FA2386-10-1-4059 AOARD-10-4059.There is no competing financial interest among the authors.A.B. designed research; S.S. designed and built the microtubule device; S.S., A.B, K.H., and S.G, performed the experiments; A.B. and S.S. analyzed the data; A.B. wrote the paper; and D.F. reviewed the work. https:\/\/aip.scitation.org\/doi\/10.1063\/1.4793995<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><a><\/a>REFERENCES<\/h4>\n\n\n\n<ol class=\"wp-block-list\"><li>1.C. T. 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Biol.&nbsp;<strong>174<\/strong>(4 ), 371\u2013380&nbsp;(1995).&nbsp;<a href=\"https:\/\/doi.org\/10.1006\/jtbi.1995.0105\" rel=\"noopener nofollow\">https:\/\/doi.org\/10.1006\/jtbi.1995.0105<\/a>&nbsp;,&nbsp;<a href=\"http:\/\/scholar.google.com\/scholar?hl=en&amp;q=%0A%0AJ.+Tuszy%C5%84ski%2C+S.+Hameroff%2C+M.+Satari%C4%87%2C+B.+Trpisova%2C+and+M.+Nip%2C+J.+Theor.+Biol.+174%284+%29%2C+371%E2%80%93380+%281995%29.+10.1006%2Fjtbi.1995.0105+\" rel=\"noopener nofollow\"><strong>Google Scholar<\/strong><\/a><strong><a href=\"https:\/\/aip.scitation.org\/servlet\/linkout?suffix=c18\/c18_1&amp;dbid=16&amp;doi=10.1063%2F1.4793995&amp;key=10.1006%2Fjtbi.1995.0105\" rel=\"noopener nofollow\">Crossref<\/a><\/strong><\/li><\/ol>\n\n\n\n<p class=\"wp-block-paragraph\">Biosens Bioelectron.&nbsp;2013 Sep 15;47:141-8.&nbsp;doi: 10.1016\/j.bios.2013.02.050.&nbsp;Epub 2013 Mar 15.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Atomic water channel controlling remarkable properties of a single brain microtubule: correlating single protein to its supramolecular assembly<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Sahu+S&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Satyajit Sahu<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23567633\/#affiliation-1\" rel=\"noopener nofollow\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ghosh+S&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Subrata Ghosh<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ghosh+B&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Batu Ghosh<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Aswani+K&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Krishna Aswani<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hirata+K&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Kazuto Hirata<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Fujita+D&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Daisuke Fujita<\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Bandyopadhyay+A&amp;cauthor_id=23567633\" rel=\"noopener nofollow\">Anirban Bandyopadhyay<\/a>Affiliations&nbsp;expand<\/p>\n\n\n\n<ul class=\"wp-block-list\" id=\"full-view-identifiers\"><li>PMID:&nbsp;<strong>23567633<\/strong><\/li><li>DOI:&nbsp;<a target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.bios.2013.02.050\" rel=\"noreferrer noopener nofollow\">10.1016\/j.bios.2013.02.050<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract<\/strong> Microtubule nanotubes are found in every living eukaryotic cells; these are formed by reversible polymerization of the tubulin protein, and their hollow fibers are filled with uniquely arranged water molecules. Here we measure single tubulin molecule and single brain-neuron extracted microtubule nanowire with and without water channel inside to unravel their unique electronic and optical properties for the first time. We demonstrate that the energy levels of a single tubulin protein and single microtubule made of 40,000 tubulin dimers are identical unlike conventional materials. Moreover, the transmitted ac power and the transient fluorescence decay (single photon count) are independent of the microtubule length. Even more remarkable is the fact that the microtubule nanowire is more conducting than a single protein molecule that constitutes the nanowire. Microtubule&#8217;s vibrational peaks condense to a single mode that controls the emergence of size independent electronic\/optical properties, and automated noise alleviation, which disappear when the atomic water core is released from the inner cylinder. We have carried out several tricky state-of-the-art experiments and identified the electromagnetic resonance peaks of single microtubule reliably. The resonant vibrations established that the condensation of energy levels and periodic oscillation of unique energy fringes on the microtubule surface, emerge as the atomic water core resonantly integrates all proteins around it such that the nanotube irrespective of its size functions like a single protein molecule. Thus, a monomolecular water channel residing inside the protein-cylinder displays an unprecedented control in governing the tantalizing electronic and optical properties of microtubule. Copyright \u00a9 2013 Elsevier B.V. All rights reserved. https:\/\/pubmed.ncbi.nlm.nih.gov\/23567633\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">El neurocient\u00edfico estadounidense <strong>Jon Lieff<\/strong> -matem\u00e1tico y doctor en Medicina y Psiquiatr\u00eda- asevera por su parte que <em>\u201cen las neuronas los microt\u00fabulos responden instant\u00e1neamente a los eventos mentales y construyen y derriban constantemente estructuras elaboradas\u201d<\/em>; a\u00f1adiendo<em>: \u201cOrquestan la reorganizaci\u00f3n y clasificaci\u00f3n del ADN durante el extremadamente elaborado proceso de divisi\u00f3n celular. Los complejos arreglos de microt\u00fabulos dirigen y extraen todos los elementos del proceso de divisi\u00f3n a trav\u00e9s de m\u00faltiples fases. La estructura de este proceso se considera la m\u00e1quina m\u00e1s compleja jam\u00e1s descubierta en la naturaleza\u201c.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y el tercer espaldarazo a la tesis lo ha dado <strong>Roderick G. Eckenhoff, <\/strong>doctor en Anestesiolog\u00eda en la <em>Penn Medicine Clinic<\/em> de la <em>Universidad de Pennsylvania<\/em> (EEUU). Hameroff llevaba tiempo afirmando que los anest\u00e9sicos que funcionan con prote\u00ednas abren unas veces las membranas de las neuronas haci\u00e9ndolas m\u00e1s activas pero otras los bloquean y no tienen pues un efecto consistente. No puede hablarse pues de un mecanismo unitario y de ah\u00ed que postulase que los anest\u00e9sicos act\u00faan en realidad anulando o inhibiendo los procesos cu\u00e1nticos que se producen en los microt\u00fabulos. Pues bien, Eckenhoff ha demostrado que los anest\u00e9sicos inducen uno u otro estado actuando sobre los microt\u00fabulos neuronales. Su trabajo apareci\u00f3 en 2013 en <em>Journal of American Chemistry Society<\/em> con el t\u00edtulo <em>Direct Modulation of Microtubule Stability Contributes to Anthracene General Anesthesia <\/em>(lo tiene en<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\" rel=\"noopener nofollow\"> <em>www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381<\/em><\/a><em>)<strong>.<\/strong><\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/#\" rel=\"noopener nofollow\">J Am Chem Soc.<\/a>&nbsp;Author manuscript; available in PMC 2013 Jun 4.<em>Published in final edited form as:<\/em><a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/eutils\/elink.fcgi?dbfrom=pubmed&amp;retmode=ref&amp;cmd=prlinks&amp;id=23484901\" rel=\"noreferrer noopener nofollow\">J Am Chem Soc. 2013 Apr 10; 135(14): 5389\u20135398.<\/a>Published online 2013 Mar 29.&nbsp;doi:&nbsp;<a target=\"_blank\" href=\"https:\/\/dx.doi.org\/10.1021%2Fja311171u\" rel=\"noreferrer noopener nofollow\">10.1021\/ja311171u<\/a>PMCID:&nbsp;PMC3671381NIHMSID:&nbsp;NIHMS468174PMID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23484901\" rel=\"noopener nofollow\">23484901<\/a> <strong>Direct Modulation of Microtubule Stability Contributes to Anthracene General Anesthesia<\/strong> <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Emerson%20DJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Daniel J. Emerson<\/a>,<sup>\u2020\u00a7<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Weiser%20BP%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Brian P. Weiser<\/a>,<sup>\u2021\u00a7<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Psonis%20J%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">John Psonis<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Liao%20Z%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Zhengzheng Liao<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Taratula%20O%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Olena Taratula<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Fiamengo%20A%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Ashley Fiamengo<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Wang%20X%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Xiaozhao Wang<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Sugasawa%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Keizo Sugasawa<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Smith%20AB%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Amos B. Smith, III<\/a>,<sup>\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Eckenhoff%20RG%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Roderic G Eckenhoff<\/a>,<sup>*\u2021<\/sup>&nbsp;and&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Dmochowski%20IJ%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=23484901\" rel=\"noopener nofollow\">Ivan J. Dmochowski<\/a><sup>*\u2020<\/sup><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/#\" rel=\"noopener nofollow\">Author informationCopyright and License information<\/a><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/about\/disclaimer\/\" rel=\"noopener nofollow\">Disclaimer<\/a>The publisher&#8217;s final edited version of this article is available at&nbsp;<a target=\"_blank\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/entrez\/eutils\/elink.fcgi?dbfrom=pubmed&amp;retmode=ref&amp;cmd=prlinks&amp;id=23484901\" rel=\"noreferrer noopener nofollow\">J Am Chem Soc<\/a>See other articles in PMC that&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/citedby\/\" rel=\"noopener nofollow\">cite<\/a>&nbsp;the published article. Associated Data <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/#\" rel=\"noopener nofollow\">Supplementary MaterialsGo to:<\/a> Abstract<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/bin\/nihms468174f7.jpg\" alt=\"An external file that holds a picture, illustration, etc.\nObject name is nihms468174f7.jpg\" title=\"Click on image to zoom\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"P3\">Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, a photoactive analogue, 1-azidoanthracene, was synthesized. Administration of 1-azidoanthracene to albino stage 40\u201347 tadpoles was found to immobilize animals upon near-UV irradiation of the forebrain region. The immobilization was often reversible, but it was characterized by a longer duration consistent with covalent attachment of the ligand to functionally important targets. IEF\/SDS-PAGE examination of irradiated tadpole brain homogenate revealed labeled protein, identified by mass spectrometry as \u03b2-tubulin. In vitro assays with aminoanthracene-cross-linked tubulin indicated inhibition of microtubule polymerization, similar to colchicine. Tandem mass spectrometry confirmed anthracene binding near the colchicine site. Stage 40\u201347 tadpoles were also incubated 1 h with microtubule stabilizing agents, epothilone D or discodermolide, followed by dosing with 1-aminoanthracene. The effective concentration of 1-aminoanthracene required to immobilize the tadpoles was significantly increased in the presence of either microtubule stabilizing agent. Epothilone D similarly mitigated the effects of a clinical neurosteroid general anesthetic, allopregnanolone, believed to occupy the colchicine site in tubulin. We conclude that neuronal microtubules are \u201con-pathway\u201d targets for anthracene general anesthetics and may also represent functional targets for some neurosteroid general anesthetics. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3671381\/<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/pubs.acs.org\/toc\/jacsat\/135\/14\" rel=\"noopener nofollow\">RETURN TO ISSUE<\/a><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja309974s\" rel=\"noopener nofollow\">PREV<\/a>ARTICLE<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja311873t\" rel=\"noopener nofollow\">NEXT<\/a> <strong>Direct Modulation of Microtubule Stability Contributes to Anthracene General Anesthesia<\/strong> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Daniel+J.++Emerson\" rel=\"noopener nofollow\">Daniel J. Emerson<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Brian+P.++Weiser\" rel=\"noopener nofollow\">Brian P. Weiser<\/a><sup>\u2021<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=John++Psonis\" rel=\"noopener nofollow\">John Psonis<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Zhengzheng++Liao\" rel=\"noopener nofollow\">Zhengzheng Liao<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Olena++Taratula\" rel=\"noopener nofollow\">Olena Taratula<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Ashley++Fiamengo\" rel=\"noopener nofollow\">Ashley Fiamengo<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Xiaozhao++Wang\" rel=\"noopener nofollow\">Xiaozhao Wang<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Keizo++Sugasawa\" rel=\"noopener nofollow\">Keizo Sugasawa<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Amos+B.++Smith%2C++III\" rel=\"noopener nofollow\">Amos B. Smith, III<\/a><sup>\u2020<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Roderic+G.++Eckenhoff\" rel=\"noopener nofollow\">Roderic G. Eckenhoff<\/a><sup>*\u2021<\/sup> <a href=\"https:\/\/pubs.acs.org\/action\/doSearch?field1=Contrib&amp;text1=Ivan+J.++Dmochowski\" rel=\"noopener nofollow\">Ivan J. Dmochowski<\/a><sup>*\u2020<\/sup> View Author Information<a href=\"https:\/\/pubs.acs.org\/action\/showCitFormats?doi=10.1021%2Fja311171u&amp;href=\/doi\/10.1021%2Fja311171u\" rel=\"noopener nofollow\"><strong>Cite this:&nbsp;<\/strong><\/a><em>J. Am. Chem. Soc.<\/em>&nbsp;2013, 135, 14, 5389\u20135398Publication Date:March 13, 2013<a class=\"\" href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/ja311171u#\" rel=\"noopener nofollow\"><\/a><a href=\"https:\/\/doi.org\/10.1021\/ja311171u\" rel=\"noopener nofollow\">https:\/\/doi.org\/10.1021\/ja311171u<\/a><strong>Copyright \u00a9 2013 American Chemical Society<\/strong><a href=\"https:\/\/pubs.acs.org\/servlet\/linkout?type=rightslink&amp;url=startPage%3D5389%26pageCount%3D10%26copyright%3DAmerican%2BChemical%2BSociety%26author%3DDaniel%2BJ.%2BEmerson%252C%2BBrian%2BP.%2BWeiser%252C%2BJohn%2BPsonis%252C%2Bet%2Bal%26orderBeanReset%3Dtrue%26imprint%3DAmerican%2BChemical%2BSociety%26volumeNum%3D135%26issueNum%3D14%26contentID%3Dja311171u%26title%3DDirect%2BModulation%2Bof%2BMicrotubule%2BStability%2BContributes%2Bto%2BAnthracene%2BGeneral%2BAnesthesia%26numPages%3D10%26pa%3D%26issn%3D0002-7863%26publisherName%3Dacs%26publication%3Djacsat%26rpt%3Dn%26endPage%3D5398%26publicationDate%3DApril%2B2013\" rel=\"noopener nofollow\">RIGHTS &amp; PERMISSIONS<\/a> Abstract<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/pubs.acs.org\/na101\/home\/literatum\/publisher\/achs\/journals\/content\/jacsat\/2013\/jacsat.2013.135.issue-14\/ja311171u\/production\/images\/medium\/ja-2012-11171u_0008.gif\" alt=\"Abstract Image\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Recently, we identified 1-aminoanthracene as a fluorescent general anesthetic. To investigate the mechanism of action, a photoactive analogue, 1-azidoanthracene, was synthesized. Administration of 1-azidoanthracene to albino stage 40\u201347 tadpoles was found to immobilize animals upon near-UV irradiation of the forebrain region. The immobilization was often reversible, but it was characterized by a longer duration consistent with covalent attachment of the ligand to functionally important targets. IEF\/SDS-PAGE examination of irradiated tadpole brain homogenate revealed labeled protein, identified by mass spectrometry as \u03b2-tubulin. In vitro assays with aminoanthracene-cross-linked tubulin indicated inhibition of microtubule polymerization, similar to colchicine. Tandem mass spectrometry confirmed anthracene binding near the colchicine site. Stage 40\u201347 tadpoles were also incubated 1 h with microtubule stabilizing agents, epothilone D or discodermolide, followed by dosing with 1-aminoanthracene. The effective concentration of 1-aminoanthracene required to immobilize the tadpoles was significantly increased in the presence of either microtubule stabilizing agent. Epothilone D similarly mitigated the effects of a clinical neurosteroid general anesthetic, allopregnanolone, believed to occupy the colchicine site in tubulin. We conclude that neuronal microtubules are \u201con-pathway\u201d targets for anthracene general anesthetics and may also represent functional targets for some neurosteroid general anesthetics. https:\/\/pubs.acs.org\/doi\/10.1021\/ja311171u<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Y es que los microt\u00fabulos neuronales son estructuras din\u00e1micas y pl\u00e1sticas que permiten moverse a la c\u00e9lula manteniendo la forma, juegan un papel clave en la divisi\u00f3n celular y son responsables de estabilizar y regular el transporte entre org\u00e1nulos y el de la propia c\u00e9lula con el exterior. El propio Hameroff demostr\u00f3 que los ultrasonidos inciden en ellos pudiendo usarse por ejemplo para modular estados y desordenes mentales. Es m\u00e1s, ello permite incluso tratar el dolor cr\u00f3nico y mejorar el estado de \u00e1nimo. Lo dio a conocer en 2013 en <em>Brain Stimulation<\/em> en un art\u00edculo titulado <em>Transcranial Ultrasound (TUS) Effects on Mental States: A Pilot Study<\/em> (est\u00e1 accesible en <a href=\"https:\/\/doi.org\/10.1016\/j.brs.2012.05.002\" rel=\"noopener nofollow\"><em>https:\/\/doi.org\/10.1016\/j.brs.2012.05.002<\/em><\/a><em>). <\/em>Unas posibilidades que confirmar\u00edan y ampliar\u00edan <strong>Jay Sanguinetti<\/strong> y <strong>John Allen<\/strong> -del departamento de Psicolog\u00eda de la <em>Universidad de Arizona<\/em> (EEUU)- con una serie de estudios que pueden consultarse en<a href=\"https:\/\/sites.google.com\/site\/tegestologist\/papers\" rel=\"noopener nofollow\"> <em>https:\/\/sites.google.com\/site\/tegestologist\/papers<\/em><\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">ELECTROCONVULSIVE THERAPY (ECT) AND OTHER METHODS ORIGINAL ARTICLE|<a href=\"https:\/\/www.brainstimjrnl.com\/issue\/S1935-861X(13)X0004-X\" rel=\"noopener nofollow\">&nbsp;VOLUME 6, ISSUE 3<\/a>,&nbsp;P409-415,&nbsp;MAY 01, 2013 <strong>Transcranial Ultrasound (TUS) Effects on Mental States: A Pilot Study<\/strong> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Stuart Hameroff<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Michael Trakas<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Chris Duffield<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Quinlan Amos<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Annemarie Buadu<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">John J. Badal<\/a> <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext#\" rel=\"noopener nofollow\">Show all authors<\/a> Published:May 30, 2012DOI:<a href=\"https:\/\/doi.org\/10.1016\/j.brs.2012.05.002\" rel=\"noopener nofollow\">https:\/\/doi.org\/10.1016\/j.brs.2012.05.002<\/a> Abstract <strong>Background\/Objective<\/strong> Transcranial ultrasound (TUS) can modulate brain function. To assess possible TUS modulation of mental states, we investigated effects on subjective reports of pain and mood of sub-thermal TUS versus placebo applied to frontal scalp and brain of chronic pain patient volunteers. <strong>Methods<\/strong> With IRB approval and informed consent, subjects with chronic pain completed two visual analog scales for pain (NRS) and mood (VAMS\/Global Affect), and their vital signs were recorded 10&nbsp;min prior to, and 10&nbsp;min and 40&nbsp;min following exposure to either subthermal TUS (8&nbsp;MHz) or placebo (in a double blind crossover study) using the 12L-RS probe of a LOGIQe ultrasound imaging machine (General Electric, USA). A physician, also blinded for TUS versus placebo, applied the probe (with gel) to scalp over posterior frontal cortex, contralateral to maximal pain, for 15 seconds. A second investigator operated the ultrasound machine, randomizing TUS versus placebo. The process was then repeated, applying the opposite modality (TUS or placebo). Results: Subjective reports of Mood\/Global Affect were improved 10&nbsp;min (<em>P<\/em>&nbsp;=&nbsp;0.03) and 40&nbsp;min (<em>P<\/em>&nbsp;=&nbsp;0.04) following TUS compared with placebo. NRS pain reports slightly improved following TUS (<em>P<\/em>&nbsp;=&nbsp;0.07) at 40&nbsp;min. <strong>Conclusion<\/strong> We found improvement in subjective mood 10&nbsp;min and 40&nbsp;min after TUS compared to placebo. TUS can have safe neurophysiological effects on brain function, and is a promising noninvasive therapy for modulating conscious and unconscious mental states and disorders. We suggest TUS acts via intra-neuronal microtubules, which apparently resonate in TUS megahertz range. <a href=\"https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext\" rel=\"noopener nofollow\">https:\/\/www.brainstimjrnl.com\/article\/S1935-861X(12)00084-8\/fulltext<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>~<\/strong>Scientific Article&nbsp;&amp;&nbsp;Philosophy Papers<strong>~<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sanguinetti, J. L<\/strong>., Trujillo, L. T., Schnyer, D. M., Allen J. B., Peterson, M. A. (in press.). Increased Alpha&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; &nbsp;&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;Indexes Inhibitory &nbsp;Competition Across a Border.&nbsp;<em>Vision Research<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Goldstein, M. R., Peterson, M. J.,&nbsp;<strong>Sanguinetti, J. L.<\/strong>, Tononi, G., &nbsp;&amp; Ferrarelli, F. (2015). Topographic deficits in &nbsp; &nbsp; &nbsp; &nbsp;alpha-range &nbsp;resting EEG activity and steady state visual evoked responses &nbsp;in schizophrenia.<em>Schizophrenia &nbsp; &nbsp; &nbsp;Research<\/em>, 168(1), 145-152.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sanguinetti, J. L.<\/strong>, Allen, J. J. B., Peterson, M. A. (2014). The Ground Side of an Object Perceived as Shapeless &nbsp; &nbsp; &nbsp; &nbsp;yet Processed for Semantics.&nbsp;<em>Psychological Science.<\/em>&nbsp;25.1 256-264.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sanguinetti, J. L.,<\/strong>&nbsp;Smith, E., Allen, J. J. B., Hameroff, S. (2014). Human brain stimulation with transcranial &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;ultrasound (TUS); Potential applications for mental health. In&nbsp;<em>Bioelectromagnetic Medicine<\/em>. (pp. 355-361), &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;New York, NY: Taylor &amp; Francis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cacciamani, L., Mojica, A. J.,&nbsp;<strong>Sanguinetti, J. L<\/strong>., &amp; Peterson, M. A. (2014). Semantic access occurs outside of &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; awareness for the ground side of a figure.&nbsp;<em>Attention, Perception, &amp; Psychophysics<\/em>, 76(8), 2531-2547.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cavanagh, J.F.,&nbsp;<strong>Sanguinetti, J.L.,<\/strong>&nbsp;Allen, J.J.B., Sherman, S.J., &amp; Frank, M.J. (2014). The subthalamic nucleus &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;contributes to post error slowing. Jounral of Cognitive Neuroscience, 26. 2637\u20132644.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Peterson M. A., Cacciamani L., Mojica D.,&nbsp;<strong>Sanguinetti J<\/strong>.<strong>L<\/strong>. (2012). Meaning can be accessed for the ground &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; region of a figure,&nbsp;<em>Gestalt Theory<\/em>,&nbsp;34(3\/4), 297-314.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/sites.google.com\/site\/tegestologist\/papers\" rel=\"noopener nofollow\">https:\/\/sites.google.com\/site\/tegestologist\/papers<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cabe a\u00f1adir que hay numerosas dolencias y trastornos directa o indirectamente relacionados con problemas en los microt\u00fabulos neuronales; son los casos de los S\u00edndromes de Joubert, Meckel, Down, Asperger, Hidroletalus, Klinefelter, Turner, Patau, Edwards y Kartagener y de patolog\u00edas como el alzheimer, el parkinson, el autismo, la epilepsia, la enfermedad poliqu\u00edstica renal, la enfermedad de Pick, la degeneraci\u00f3n cortico-basal, la par\u00e1lisis supranuclear progresiva, la demencia frontotemporal, la enfermedad de los granos argir\u00f3filos, la demencia ligada al cromosoma 17, la distrofia de Duchenne, el tumor neuroectod\u00e9rmico primitivo, el Sarcoma de Ewing y otras.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>\u201cLa gran mayor\u00eda de las enfermedades asociadas a microt\u00fabulos son complejas <\/em>-explica el doctor <strong>Jens L\u00fcdens<\/strong>, del <em>Institut de Investigaci\u00f3n Biom\u00e9dica<\/em> de Barcelona- <em>porque hay muchas prote\u00ednas implicadas en el correcto funcionamiento de los filamentos. El reto es pues entender a nivel molecular c\u00f3mo se forma y remodela la red de microt\u00fabulos. Ya tenemos identificadas cientos de prote\u00ednas y componentes relacionadas con c\u00f3mo se organizan y ahora hay que entender c\u00f3mo trabajan juntos y mejorar las t\u00e9cnicas y herramientas que nos permitan estudiar en detalle unas estructuras celulares tan extremadamente din\u00e1micas\u201d.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>LOS MICROTUBULOS Y EL \u00abAGUA VIVA\u00bb<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En suma, a\u00fan estamos empezando a entender el papel que juegan los microt\u00fabulos celulares pero el hecho de que puedan tener un papel que va m\u00e1s all\u00e1 de lo puramente f\u00edsico los convierte en un asunto de enorme relevancia. De ah\u00ed que quisi\u00e9ramos conocer la opini\u00f3n de <strong>Mar\u00eda Jes\u00fas Bl\u00e1zquez<\/strong>, bi\u00f3loga espa\u00f1ola reci\u00e9n jubilada tras 38 a\u00f1os impartiendo clases, autora de la obra <em>Huellas y semillas<\/em> y fundadora de la <em>Asociaci\u00f3n V\u00eda L\u00e1ctea<\/em> y del <em>Colectivo Otra Biolog\u00eda<\/em>, \u00e9ste junto a grupo de profesores cuyo referente es el profesor <strong>M\u00e1ximo Sand\u00edn<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-Parece que no sab\u00edamos tanto como cre\u00edamos de las c\u00e9lulas\u2026<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-Es cierto. Especialmente porque hoy sabemos que es como una antena receptora\/emisora cuyo mundo es una aut\u00e9ntica coreograf\u00eda vital. Nada que ver con la simpleza de la c\u00e9lula escolar de los libros de texto en los que aparece como una especie de bolsa en la que el ADN controlar\u00eda todo.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-Lo planteado por Hameroff y Penrose pone desde luego en entredicho que el cerebro se comunique solo mediante impulsos nerviosos.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-Est\u00e1 constatado que las c\u00e9lulas se enteran al un\u00edsono de todo y casi de forma instant\u00e1nea. Y no solo a trav\u00e9s de las sustancias que transporta la sangre y de los impulsos nerviosos sino mediante el env\u00edo y recepci\u00f3n de paquetes de energ\u00eda e informaci\u00f3n merced a las fibras de col\u00e1geno -que son semiconductoras- y del \u00abagua de cristal\u00bb de nuestro organismo. O dicho de otro modo, gracias a nuestra \u00abmatriz viviente\u00bb como la llama el biof\u00edsico estadounidense <strong>James Oschman<\/strong> en su libro <em>Medicina energ\u00e9tica: la base cient\u00edfica.<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-\u00bfEst\u00e1 entonces sobrevalorado el papel del ADN?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-En mis clases y conferencias sol\u00eda hacer bailar un pa\u00f1uelo para hacer un s\u00edmil con la forma en la que vibra el ADN. Hoy sabemos que seg\u00fan estemos -estirados, encogidos, bailando, respirando con calma, preocupados, frustrados, alegres\u2026- as\u00ed se pliega nuestro ADN. \u00bfY c\u00f3mo se entera el ADN de nuestro estado de \u00e1nimo estando encerrado en el n\u00facleo celular? Pues porque las c\u00e9lulas no est\u00e1n aisladas: tienen en las membranas unas prote\u00ednas -las integrinas- que comunican todo a los microt\u00fabulos. Y \u00e9stos son como cuerdas que trasmiten todo al ADN\u2026 vibrando. Y es que al final \u00a1todo es vibraci\u00f3n! Por eso dice Hameroff que los microt\u00fabulos son como tuber\u00edas de luz, gu\u00edas de ondas para los fotones que pasan de c\u00e9lula a c\u00e9lula sin p\u00e9rdida alguna de energ\u00eda.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-Luego problemas en los microt\u00fabulos neuronales pueden dar lugar a problemas cerebrales\u2026<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-Ciertamente. Se ha comprobado que en las neuronas de los enfermos de alzheimer hay microt\u00fabulos rotos. Y no olvidemos que en su interior hay agua estructurada capaz de guardar informaci\u00f3n y transmitirla. Y que los microt\u00fabulos conectan el mundo intracelular con el cuerpo energ\u00e9tico y su biocampo; lo que acerca la ciencia puntera a la conciencia y a la espiritualidad.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-\u00bfQuiere decir que el agua estructurada del organismo tiene \u00abmemoria\u00bb?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-Sin la menor duda. Lo postulado por Hameroff y Penrose explica cosas como que seamos capaces de recordar y revivir sucesos de nuestra vida intrauterina as\u00ed como las experiencias cercanas a la muerte. Aun estando inconscientes y aletargados nuestros sentidos somos capaces de recopilar informaci\u00f3n y trasmitirla luego con riqueza de detalles.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-Tenemos pues m\u00e1s preguntas que respuestas. \u00bfY cu\u00e1l es su opini\u00f3n general sobre las hip\u00f3tesis de esos dos cient\u00edficos?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-Mi opini\u00f3n es que nuestras preguntas no va a poder responderlas la ciencia por s\u00ed sola. Dudo que pueda explicarse el funcionamiento de la vida con un modelo matem\u00e1tico. Los microt\u00fabulos se montan y desmontan como legos y lo hacen en forma de espiral, pero \u00bfqui\u00e9n ha decidido que eso sea as\u00ed? \u00bfEl azar? No, yo creo que haya nada al azar \u00a1ni en los juegos de azar! Sabemos que en caso de enfermedad nuestra agua interna se desestructura, se desordena. \u00bfQui\u00e9n ha hecho que eso sea as\u00ed? \u00bfEl azar de nuevo? A m\u00ed el argumento de que el fant\u00e1stico funcionamiento del universo entero se debe al azar me parece infantil, no \u00abcient\u00edfico\u00bb.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-\u00bfQu\u00e9 pasa con nuestra agua interior en caso de enfermedad?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-El agua de nuestro organismo tiene una estructura diferente a la del agua ordinaria. Sus mol\u00e9culas se mueven en una vertiginosa danza en espiral en grupos de seis formando hex\u00e1gonos en una cien millon\u00e9sima de segundo mediante enlaces de hidr\u00f3geno. Y para que ese movimiento sea posible se precisan espacios con formas geom\u00e9tricas especiales como el ovoide. No es casual que los alveolos mamarios -donde se encuentran las c\u00e9lulas que forman la leche- sean de forma ovoide y ello facilite el movimiento en espiral, forma universal que se repite en toda la naturaleza.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Si perdemos capacidades con la edad y la enfermedad es porque en ambos casos disminuye sobre todo la cantidad de agua estructurada de nuestro interior. F\u00edjese que en el calostro hay un 87,2% de agua y en la leche madura un 88%. Y en la vida todas las cosas tienen un motivo\u2026<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>-Penrose y Hameroff no mencionan este tipo de agua entre sus postulados\u2026<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">-No. Y sin embargo su existencia apoya lo que plantean. Hablamos de un agua viva que se comporta como una matriz organizada capaz de transportar se\u00f1ales, vibraciones e informaci\u00f3n de forma parecida a como lo hacen los cristales de los circuitos electr\u00f3nicos de alta tecnolog\u00eda. De hecho cumple la misma funci\u00f3n, es decir, amplificar y transmitir se\u00f1ales en un instante y transportar todo el espectro de secuencias de la vida. Todas las c\u00e9lulas del organismo est\u00e1n interconectadas mediante una red de comunicaci\u00f3n de alt\u00edsima velocidad.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hasta aqu\u00ed la entrevista. Nosotros terminamos este texto recordando que la aseveraci\u00f3n de que los seres humanos estamos hechos de un agua especial compuesta de cristales l\u00edquidos en forma de clatratos que permiten que la luz \u2013y, por ende, la energ\u00eda-&nbsp;viaje a velocidades incre\u00edbles por nuestro organismo transmitiendo informaci\u00f3n lo postul\u00f3 hace ya muchos a\u00f1os doctora mexicana<strong> Esther del R\u00edo<\/strong> as\u00ed como que su p\u00e9rdida es una de las principales causas de enfermedad por lo que su restituci\u00f3n permite recuperar la salud. Seg\u00fan explica el agua de nuestro cuerpo es en su mayor parte de cristal-l\u00edquido y posee por ello tanto las propiedades de los l\u00edquidos como las de los cristales; entre ellas la de almacenar y transmitir informaci\u00f3n de formas casi instant\u00e1nea. De ah\u00ed que nuestras c\u00e9lulas se comuniquen al igual que lo hacen las pantallas de cristal l\u00edquido y puedan hasta enviar y recibir hologramas codificados siendo pues los humanos \u201cel mejor ordenador\u201d del mundo\u201d. Lo dimos a conocer en el reportaje que con el t\u00edtulo <em>Por las venas corre \u00a1luz! <\/em>apareci\u00f3 en el n\u00ba 85 correspondiente a julio de 2006.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Jes\u00fas Garc\u00eda Blanca<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Stuart Hameroff<\/strong>&nbsp;( *&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1947\" rel=\"noopener nofollow\">1947<\/a>&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/B%C3%BAfalo_(Nueva_York)\" rel=\"noopener nofollow\">B\u00fafalo<\/a>,&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Nueva_York_(estado)\" rel=\"noopener nofollow\">Nueva York<\/a>) es un&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Anestesista\" rel=\"noopener nofollow\">anestesista<\/a>&nbsp;y profesor de la&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Universidad_de_Arizona\" rel=\"noopener nofollow\">Universidad de Arizona<\/a>,<sup><a href=\"https:\/\/es.wikipedia.org\/wiki\/Stuart_Hameroff#cite_note-cv-1\" rel=\"noopener nofollow\">1<\/a><\/sup>\u200b conocido por promover el estudio cient\u00edfico de la&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Conciencia_(Psicolog%C3%ADa)\" rel=\"noopener nofollow\">conciencia<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hameroff recibi\u00f3 la graduaci\u00f3n&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Bachelor_of_Science\" rel=\"noopener nofollow\">BS<\/a>&nbsp;en la&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Universidad_de_Pittsburgh\" rel=\"noopener nofollow\">Universidad de Pittsburgh<\/a>&nbsp;y su graduaci\u00f3n como&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Doctor_en_Medicina\" rel=\"noopener nofollow\">doctor en Medicina<\/a>&nbsp;en el Hospital Universitario Hahnemann (ahora parte del&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Universidad_Drexel\" rel=\"noopener nofollow\">Colegio Universitario de Medicina Drexel<\/a>). Se traslad\u00f3 al&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Centro_m%C3%A9dico_de_Tucson\" rel=\"noopener nofollow\">Centro m\u00e9dico de Tucson<\/a>&nbsp;en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1973\" rel=\"noopener nofollow\">1973<\/a>. De&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1977\" rel=\"noopener nofollow\">1977<\/a>&nbsp;en adelante su carrera ha transcurrido en la&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/Universidad_de_Arizona\" rel=\"noopener nofollow\">Universidad de Arizona<\/a>, donde fue nombrado profesor en los departamentos de anestesiolog\u00eda y psicolog\u00eda en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1995\" rel=\"noopener nofollow\">1995<\/a>, director asociado para el&nbsp;<a href=\"https:\/\/es.wikipedia.org\/w\/index.php?title=Centro_de_Estudios_de_la_Conciencia_de_la_Universidad_de_Arizona&amp;action=edit&amp;redlink=1\" rel=\"noopener nofollow\">Centro de Estudios de la Conciencia<\/a>&nbsp;en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1999\" rel=\"noopener nofollow\">1999<\/a>, profesor em\u00e9rito en anestesiolog\u00eda y psicolog\u00eda en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/2003\" rel=\"noopener nofollow\">2003<\/a>, y director del Centro de Estudios de la Conciencia en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/2004\" rel=\"noopener nofollow\">2004<\/a>&nbsp;(hab\u00eda sido cofundador de este centro en&nbsp;<a href=\"https:\/\/es.wikipedia.org\/wiki\/1998\" rel=\"noopener nofollow\">1998<\/a>).<sup><a href=\"https:\/\/es.wikipedia.org\/wiki\/Stuart_Hameroff#cite_note-cv-1\" rel=\"noopener nofollow\">1<\/a><\/sup>\u200b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;<a href=\"http:\/\/anesth.medicine.arizona.edu\/faculty\/stuart-r-hameroff-md\" rel=\"noopener nofollow\">\u00abStuart R. Hameroff, MD\u00bb<\/a>.&nbsp;<em><a href=\"https:\/\/es.wikipedia.org\/wiki\/Universidad_de_Arizona\" rel=\"noopener nofollow\">Universidad de Arizona<\/a><\/em>&nbsp;(en ingl\u00e9s). Consultado el 18 de agosto de 2016.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>REVIEW \u00bfSe manifiesta la conciencia a trav\u00e9s de las neuronas cerebrales? 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