Adjuvant

Abstract Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Whether SARS-CoV-2 is augmented by ADE remains undetermined and has therefore garnered criticism for the improper attribution of the phenomenon to the pandemic. Thus, critical evaluation of ADE in SARS-CoV-2 vaccine development will be indispensable to avoid a global setback and the erosion of public trust.

02/11/21•BIG PHARMA › VIEWS

Scientists Warn of Potential COVID Vaccine-Related ‘Ticking Time Bomb’

Studies suggest that COVID vaccines may trigger antibody-dependent enhancement in some people, a condition that could cause them to develop more severe symptoms when exposed to the wild virus than if they hadn’t been vaccinated.By Rob Verkerk Ph.D.

Careful readers of Halstead and Katzelnick’s paper will note that while the authors largely dismiss the ADE risk, they very clearly identify a risk of vaccine hypersensitivity (or VAH), a closely related immunological hyper-reaction that was first identified in the late 1960s when children developed atypical measles following measles vaccination.

Many who’ve used the paper to dismiss ADE risks may only have read the title and abstract and not picked up that Katzelnick and Halstead dismiss only intrinsic ADE or iADE (i.e. the risk of disease enhancement on re-infection in the absence of vaccination).

They also may not have read the sombre advisory in the paper’s last sentence: “Given the magnitude of the repertoire of COVID-19 problems and the need for an effective vaccine, the full force of worldwide investigative resources should be directed at unravelling the pathogenesis of VAH.”

Robert F. Kennedy Jr.

The Real Anthony Fauci: Bill Gates, Big Pharma, and the Global War on Democracy and Public Health (Children’s Health Defense)

5.0 de 5 estrellas (1)Opiniones#1 más vendido en Inmunología

11/05/21•COVID › NEWS

We’re Not in a ‘Pandemic of the Unvaccinated,’ Peter Doshi Explains During COVID Panel

Peter Doshi, a senior editor at The BMJ, and Retsef Levi, a professor at the Massachusetts Institute of Technology, told a panel of experts the COVID vaccines’ trial data doesn’t support the narrative that the vaccines are safe and effective.By Jeremy Loffredo

Senior NIH expert pushes back on growing vaccine mandates

Matthew Memoli favors vaccinations in vulnerable populations but argues population level vaccination could hinder the development of a natural, robust immunity gained through infection.ByAdam Barnes | Nov. 8, 2021

Esto es lo que NO se nos dice sobre las vacunas y el autismo:

“Los anticuerpos de la triple vírica son significativamente más altos en los niños autistas en comparación con los niños normales, lo que apoya un papel de la triple vírica en el autismo”.

Immunological findings in autism

Hari Har Parshad Cohly et al. Int Rev Neurobiol. 2005.

Abstract The immunopathogenesis of autism is presented schematically in Fig. 1. Two main immune dysfunctions in autism are immune regulation involving pro-inflammatory cytokines and autoimmunity. Mercury and an infectious agent like the measles virus are currently two main candidate environmental triggers for immune dysfunction in autism. Genetically immune dysfunction in autism involves the MHC region, as this is an immunologic gene cluster whose gene products are Class I, II, and III molecules. Class I and II molecules are associated with antigen presentation. The antigen in virus infection initiated by the virus particle itself while the cytokine production and inflammatory mediators are due to the response to the putative antigen in question. The cell-mediated immunity is impaired as evidenced by low numbers of CD4 cells and a concomitant T-cell polarity with an imbalance of Th1/Th2 subsets toward Th2. Impaired humoral immunity on the other hand is evidenced by decreased IgA causing poor gut protection. Studies showing elevated brain specific antibodies in autism support an autoimmune mechanism. Viruses may initiate the process but the subsequent activation of cytokines is the damaging factor associated with autism. Virus specific antibodies associated with measles virus have been demonstrated in autistic subjects. Environmental exposure to mercury is believed to harm human health possibly through modulation of immune homeostasis. A mercury link with the immune system has been postulated due to the involvement of postnatal exposure to thimerosal, a preservative added in the MMR vaccines. The occupational hazard exposure to mercury causes edema in astrocytes and, at the molecular level, the CD95/Fas apoptotic signaling pathway is disrupted by Hg2+. Inflammatory mediators in autism usually involve activation of astrocytes and microglial cells. Proinflammatory chemokines (MCP-1 and TARC), and an anti-inflammatory and modulatory cytokine, TGF-beta1, are consistently elevated in autistic brains. In measles virus infection, it has been postulated that there is immune suppression by inhibiting T-cell proliferation and maturation and downregulation MHC class II expression. Cytokine alteration of TNF-alpha is increased in autistic populations. Toll-like-receptors are also involved in autistic development. High NO levels are associated with autism. Maternal antibodies may trigger autism as a mechanism of autoimmunity. MMR vaccination may increase risk for autism via an autoimmune mechanism in autism. MMR antibodies are significantly higher in autistic children as compared to normal children, supporting a role of MMR in autism. Autoantibodies (IgG isotype) to neuron-axon filament protein (NAFP) and glial fibrillary acidic protein (GFAP) are significantly increased in autistic patients (Singh et al., 1997). Increase in Th2 may explain the increased autoimmunity, such as the findings of antibodies to MBP and neuronal axonal filaments in the brain. There is further evidence that there are other participants in the autoimmune phenomenon. (Kozlovskaia et al., 2000). The possibility of its involvement in autism cannot be ruled out. Further investigations at immunological, cellular, molecular, and genetic levels will allow researchers to continue to unravel the immunopathogenic mechanisms’ associated with autistic processes in the developing brain. This may open up new avenues for prevention and/or cure of this devastating neurodevelopmental disorder.

“Nuestros resultados proporcionan una fuerte evidencia que apoya un vínculo entre el autismo y el aluminio en las vacunas…” ~ Entropía 2012

Empirical Data Confirm Autism Symptoms Related to Aluminum and Acetaminophen Exposure ^†

by Stephanie Seneff ^1,*,Robert M. Davidson ² andJingjing Liu ¹

“En conclusión, la persistencia a largo plazo del hidróxido de aluminio derivado de las vacunas dentro del cuerpo evaluado por la MMF se asocia con la disfunción cognitiva”

Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Maryline Couette et al. J Inorg Biochem. 2009 Nov.

*** “Nuestros resultados muestran que los niños de los países con mayor prevalencia del Trastorno del Espectro Autista parecen tener la mayor exposición al aluminio de las vacunas.” ~ Journal of Inorganic Biochemistry

Efectos tóxicos del aluminio como adyuvante de las vacunas “Todos estos hallazgos implican plausiblemente a los adyuvantes de Al en las vacunas pediátricas como factores causales del aumento de las tasas de trastornos del espectro autista en los países donde se administran universalmente múltiples dosis.”

Aluminum-Induced Entropy in Biological Systems: Implications for Neurological Disease

Christopher A. Shaw, Stephanie Seneff, […], and Robert M. Davidson

El aluminio en las vacunas infantiles no es seguro- Journal of American Physicians and Surgeons Volumen 21 Número 4 Invierno 2016

Biopersistencia y translocación cerebral de los adyuvantes de aluminio de las vacunas.

Biopersistence and Brain Translocation of Aluminum Adjuvants of Vaccines

Romain Kroum Gherardi, Housam Eidi, […], and Josette Cadusseau

El CDC sí encontró una relación entre la triple vírica y el autismo en un estudio de 2001, pero ordenó a sus científicos que destruyeran los datos. El Dr. William Thompson se convirtió en denunciante y entregó sus copias originales del estudio al congreso.

Master Manipulator: The Explosive True Story of Fraud, Malversación, and Government Betrayal at the CDC. Se trata del tipo que hizo el estudio que “probaba” que la triple vírica no causaba autismo, pero era un fraude y malversó dinero de los fondos del estudio.

REVIEW “Por lo tanto, los niños autistas tienen una respuesta hiperinmune al virus del sarampión, que en ausencia de un tipo salvaje de infección de sarampión podría ser un signo de una reacción inmune anormal a la cepa de la vacuna o la reactivación del virus.”

“En otras palabras, casi todos los niños seguidos en el estudio que desarrollaron autismo (88%) tenían autismo regresivo. Eso significa que NO nacieron con él, sino que experimentaron un declive significativo de sus funciones después de un factor de estrés ambiental.”

Onset patterns in autism: Variation across informants, methods, and timing

Sally Ozonoff et al. Autism Res. 2018 May.Free PMC article

Abstract While previous studies suggested that regressive forms of onset were not common in autism spectrum disorder (ASD), more recent investigations suggest that the rates are quite high and may be under-reported using certain methods. The current study undertook a systematic investigation of how rates of regression differed by measurement method. Infants with (n = 147) and without a family history of ASD (n = 83) were seen prospectively for up to 7 visits in the first three years of life. Reports of symptom onset were collected using four measures that systematically varied the informant (examiner vs. parent), the decision type (categorical [regression absent or present] vs. dimensional [frequency of social behaviors]), and the timing of the assessment (retrospective vs. prospective). Latent class growth models were used to classify individual trajectories to see whether regressive onset patterns were infrequent or widespread within the ASD group. A majority of the sample was classified as having a regressive onset using either examiner (88%) or parent (69%) prospective dimensional ratings. Rates of regression were much lower using retrospective or categorical measures (from 29 to 47%). Agreement among different measurement methods was low. Declining trajectories of development, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The accuracy of widely used methods of measuring onset is questionable and the present findings argue against their widespread use. Autism Res 2018, 11: 788-797. © 2018 International Society for Autism Research, Wiley Periodicals, Inc.

Lay summary: This study examines different ways of measuring the onset of symptoms in autism spectrum disorder (ASD). The present findings suggest that declining developmental skills, consistent with a regressive onset pattern, are common in children with ASD and may be more the rule than the exception. The results question the accuracy of widely used methods of measuring symptom onset and argue against their widespread use.

Keywords: early signs; infants; regression.

© 2018 International Society for Autism Research, Wiley Periodicals, Inc.

¿Qué es el autismo regresivo y por qué se produce? ¿Es la consecuencia de una disfunción multisistémica que afecta a la eliminación de metales pesados y a la capacidad de regular la temperatura neuronal?

What is regressive autism and why does it occur? Is it the consequence of multi-systemic dysfunction affecting the elimination of heavy metals and the ability to regulate neural temperature?

Graham E. Ewing

Concentraciones de metales tóxicos en el cabello y gravedad del trastorno del espectro autista en niños pequeños

Hair Toxic Metal Concentrations and Autism Spectrum Disorder Severity in Young Children

David A. Geier, Janet K. Kern, […], and Mark R. Geier

Statistical analysis [S]imilarly, investigators described that Hg is widespread and persistent in the environment [29,30,31]. Hg is a ubiquitous source of danger in fish, drugs, fungicides/herbicides, dental fillings, thermometers, vaccines, and many other products/food stuffs. Elevated Hg concentrations may remain in the brain from several years to decades following exposure.

“El aluminio en forma de adyuvante conlleva el riesgo de autoinmunidad, inflamación cerebral a largo plazo, complicaciones neurológicas asociadas y tiene profundas y amplias consecuencias adversas para la salud”. Current Medicinal Chemistry vol. 18 número 17 junio 2011 pp 263

Aluminum vaccine adjuvants: are they safe?

L Tomljenovic et al. Curr Med Chem. 2011.

Abstract Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s understanding about their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted. Experimental research, however, clearly shows that aluminum adjuvants have a potential to induce serious immunological disorders in humans. In particular, aluminum in adjuvant form carries a risk for autoimmunity, long-term brain inflammation and associated neurological complications and may thus have profound and widespread adverse health consequences. In our opinion, the possibility that vaccine benefits may have been overrated and the risk of potential adverse effects underestimated, has not been rigorously evaluated in the medical and scientific community. We hope that the present paper will provide a framework for a much needed and long overdue assessment of this highly contentious medical issue.

Metales pesados y autismo.

Un estudio encuentra “algunos de los valores más altos de aluminio en tejido cerebral humano registrados hasta ahora” en cerebros de pacientes autistas. “Hoy en día, los bebés reciben dosis múltiples sin precedentes de vacunas con adyuvantes de aluminio”.

Study Finds “Some of the Highest Values for Aluminium in Human Brain Tissue Yet Recorded” in Brains of Autistic Patients

POSTED BY CELESTE MCGOVERN ON NOV 28, 2017 5:29:23 PM

A 15-year-old autistic boy had one tissue sample with levels of aluminum 22 times higher than those found in healthy individuals. Researchers suggest that childhood vaccines are a potential source of the toxic metal.