- Señor (1997), p. 276.
- ↑ Ortega (2013), p. 1715.
- ↑ Palomo (2013), p. 24.
Peter Navarro In Trump Time: My Journal of America’s Plague Year 4.9 de 5 estrellas (209)OpinionesAmazon Charts #9 esta semana
Anthony “Ngọc Trí” Phan (born November 27, 1993) is an Americanpolitician currently serving as a member of the Milpitas City Council.[1] Elected at the age of 22,[2] he is one of the youngest elected officials in the US.
[1] Mohammed, Aliyah (December 8, 2016). “Milpitas: New council, school board to be sworn in on Dec. 13”. Mercury News. Bay Area News Group. Retrieved December 20, 2016.
The Internet of Bodies Will Change Everything, for Better or Worse October 29, 2020 OVERVIEW The rise of devices that connect the human body to the web is accelerating rapidly. This Internet of Bodies could revolutionize health care and improve our quality of life. But without appropriate guardrails, it could also jeopardize our most intimate personal information and introduce several ethical concerns. Topline The Internet of Bodies is about to transform everything from health care to auto safety. A new RAND study examines how to leverage the potential benefits—and mitigate the risks.
La doble moral de la Cumbre del Clima: viajes en jet privados o un menú lleno de carne Líderes de todo el mundo discuten en Glasgow sobre la lucha contra el cambio climático mientras su huella de CO2 durante estas dos semanas es mayor a la de meses de cualquier ciudadano del planeta En redes sociales, se viralizó una imagen (aunque posteriormente se ha demostrado que no pertenece a este año) en el que aparecían una gran cantidad de aeronaves de este tipo. “Más de 400 jets privados en la Cumbre Climática de Glasgow para decirte que tu furgoneta diésel va a acabar con la Tierra”, decía el usuario de Twitter que compartió la fotografía. Aunque se estima que hubo 182 vuelos de este tipo (menos de la mitad de los que se decía), según datos del servicio FlightRadar24, lo cierto es que a esa frase divulgada en la red social no le falta razón. El presidente de Estados Unidos, Joe Biden, viajó de Washington a Roma y luego de Roma a Glasgow; su gira europea ha costado toneladas de CO2, contaminando más que una persona que viaja con su coche o furgoneta por España.
About Flightradar24 Flightradar24 is a global flight tracking service that provides you with real-time information about thousands of aircraft around the world. Flightradar24 tracks 180,000+ flights, from 1,200+ airlines, flying to or from 4,000+ airports around the world in real time. Our service is currently available online and for your iOS or Android device.
READ Cash cow endless vaccine
“Yo nunca tuve Covid”: las polémicas declaraciones de Paty Navidad en los Premios de la Radio La actriz mencionó que no estaba preocupada por contagiarse y que tampoco se arrepentía de evitar la aplicación de la vacuna 11 de Noviembre de 2021
Los doctores me decían que estaba muriendo y que tenía doble neumonía, y me quise salir dos veces porque era mentira, el primer lugar porque yo no era para estar en terapia intensiva con 25 cables en cada caso. Si hubiera permitido que me intubaran, sin ser necesario, posiblemente no estaría aquí, como ha sucedido a muchísimas personas, también de mi misma familia desgraciadamente
A mediados de año, a través de su cuenta de Instagram, Paty además escribió que considera que la inmunización es “un derecho, no una obligación”, pues en distintas ocasiones ha hablado en contra de la vacuna y explicó sus razones para no hacerlo. “Nota aclaratoria”, comenzó en el mensaje. “A quien corresponda: No me he vacunado, ni me vacunaré. La vacuna es un derecho, no una obligación. Y también es un experimento del que nadie se hace responsable, excepto quien decide vacunarse”.
Liberalotes, libertarios y la contradicción de subordinarse al líder mesiánico
Bjorn StevensMeteorólogo
There is an Internet of Senses Institute dedicated to the digitization of hearing, sight, smell, taste, and touch.
Whitley Strieber Hombre de mimbre
Can we turn unwanted carbon dioxide Into electricity?
New power plant design to expand use of geothermal energy in the U.S.
Researchers are developing a new kind of geothermal power plant that will lock away unwanted carbon dioxide (CO₂) underground and use it as a tool to boost electric power generation by at least 10 times compared to existing geothermal energy approaches.
Carbon capture system turns CO2 into electricity and hydrogen fuel
By Michael IrvingJanuary 22, 2019 (NASICON)%20membrane.&text=When%20CO2%20is%20injected%20into,generates%20electricity%20and%20creates%20hydrogen.
Scientists have developed a new device that can absorb CO2 and produce electricity and hydrogen fueljordano/DepositphotosVIEW 2 IMAGES
If we’re going to reach the goal of keeping Earth from warming more than 1.5° C (2.7° F) this century, it’s not enough to just reduce our carbon dioxide emissions – we need to actively clean it out of the atmosphere too. Inspired by the ocean’s role as a natural carbon sink, researchers at Ulsan National Institute of Science and Technology (UNIST) and Georgia Tech have developed a new system that absorbs CO2 and produces electricity and useable hydrogen fuel.
Energy from seawater
Researchers develop technology to harness energy from mixing of freshwater and seawater
Date:July 29, 2019Source:Stanford UniversitySummary:A new battery made from affordable and durable materials generates energy from places where salt and fresh waters mingle. The technology could make coastal wastewater treatment plants energy-independent and carbon neutral.
FULL STORY Salt is power. It might sound like alchemy, but the energy in places where salty ocean water and freshwater mingle could provide a massive source of renewable power. Stanford researchers have developed an affordable, durable technology that could harness this so-called blue energy.
The paper, recently published in American Chemical Society’s ACS Omega, describes the battery and suggests using it to make coastal wastewater treatment plants energy-independent.
“Blue energy is an immense and untapped source of renewable energy,” said study coauthor Kristian Dubrawski, a postdoctoral scholar in civil and environmental engineering at Stanford. “Our battery is a major step toward practically capturing that energy without membranes, moving parts or energy input.”
Water power Every cubic meter of freshwater that mixes with seawater produces about .65 kilowatt-hours of energy — enough to power the average American house for about 30 minutes. Globally, the theoretically recoverable energy from coastal wastewater treatment plants is about 18 gigawatts — enough to power more than 1,700 homes for a year.
Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity
a Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou, P.R. China
E-mail: zliu@suda.edu.cn, rpeng@suda.edu.cn
b CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology of China, Beijing, P.R. China
Abstract Benefiting from their unique physicochemical properties, graphene derivatives have attracted great attention in biomedicine. In this study, we carefully engineered graphene oxide (GO) as a vaccine adjuvant for immunotherapy using urease B (Ure B) as the model antigen. Ure B is a specific antigen for Helicobacter pylori, which is a class I carcinogen for gastric cancer. Polyethylene glycol (PEG) and various types of polyethylenimine (PEI) were used as coating polymers. Compared with single-polymer modified GOs (GO–PEG and GO–PEI), certain dual-polymer modified GOs (GO–PEG–PEI) can act as a positive modulator to promote the maturation of dendritic cells (DCs) and enhance their cytokine secretion through the activation of multiple toll-like receptor (TLR) pathways while showing low toxicity. Moreover, this GO–PEG–PEI can serve as an antigen carrier to effectively shuttle antigens into DCs. These two advantages enable GO–PEG–PEI to serve as a novel vaccine adjuvant. In the subsequent in vivo experiments, compared with free Ure B and clinically used aluminum-adjuvant-based vaccine (Alum-Ure B), GO–PEG–PEI–Ure B induces stronger cellular immunity via intradermal administration, suggesting promising applications in cancer immunotherapy. Our work not only presents a novel, highly effective GO-based vaccine nano-adjuvant, but also highlights the critical roles of surface chemistry for the rational design of nano-adjuvants.
Acta Biomaterialia Volume 112, August 2020, Pages 14-28
Recent progress of graphene oxide as a potential vaccine carrier and adjuvant
Author links open overlay panelaSichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu, Sichuan, ChinabSchool of Pharmacy, North Sichuan Medical College, Nanchong, ChinacSchool of Materials, University of Electronic Science and Technology of China, Chengdu, China
Received 15 February 2020, Revised 28 April 2020, Accepted 3 June 2020, Available online 10 June 2020.
Abstract Vaccine is one of the most effective strategies for preventing and controlling infectious diseases and some noninfectious diseases, especially cancers. Adjuvants and carriers have been appropriately added to the vaccine formulation to improve the immunogenicity of the antigen and induce long-lasting immunity. However, there is an urgent need to develop new all-purpose adjuvants because some adjuvants approved for human use have limited functionality. Graphene oxide (GO), widely employed for the delivery of biomolecules, excels in loading and delivering antigen and shows the potentiality of activating the immune system. However, GO aggregates in biological liquid and induces cell death, and it also exhibits poor biosolubility and biocompatibility. To address these limitations, various surface modification protocols have been employed to integrate aqueous compatible substances with GO to effectively improve its biocompatibility. More importantly, these modifications render functionalized-GO with superior properties as both carriers and adjuvants. Herein, the recent progress of physicochemical properties and surface modification strategies of GO for its application as both carriers and adjuvants is reviewed.
Statement of Significance
Due to its unique physicochemical properties, graphene oxide is widely employed in medicine for purposes of photothermal treatment of cancer, drug delivery, antibacterial therapy, and medical imaging. Our work describes the surface modification of graphene oxide and for the first time summarizes that functionalized graphene oxide serves as a vaccine carrier and shows significant adjuvant activity in activating cellular and humoral immunity. In the future, it is expected to be introduced into vaccine research to improve the efficacy of vaccines.
Robert W Malone, MD@RWMaloneMDI take no pleasure in observing that this sounds a lot like vindication of much of what I have been saying. And by the way, Reuters, the SARS-CoV-2 Spike protein is a toxin…8:59 a. m. · 30 jul. 2021·Twitter Web App
Exploration of graphene oxide as an intelligent platform for cancer vaccines
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Abstract We explored an intelligent vaccine system via facile approaches using both experimental and theoretical techniques based on the two-dimensional graphene oxide (GO). Without extra addition of bio/chemical stimulators, the microsized GO imparted various immune activation tactics to improve the antigen immunogenicity. A high antigen adsorption was acquired, and the mechanism was revealed to be a combination of electrostatic, hydrophobic, and π-π stacking interactions. The “folding GO” acted as a cytokine self-producer and antigen reservoir and showed a particular autophagy, which efficiently promoted the activation of antigen presenting cells (APCs) and subsequent antigen cross-presentation. Such a “One but All” modality thus induced a high level of anti-tumor responses in a programmable way and resulted in efficient tumor regression in vivo. This work may shed light on the potential use of a new dimensional nano-platform in the development of high-performance cancer vaccines.We explored an intelligent vaccine system via facile approaches using both experimental and theoretical techniques based on the two-dimensional graphene oxide (GO). Without extra addition of bio/chemical stimulators, the microsized GO imparted various immune activation tactics to improve the antigen immunogenicity. A high antigen adsorption was acquired, and the mechanism was revealed to be a combination of electrostatic, hydrophobic, and π-π stacking interactions. The “folding GO” acted as a cytokine self-producer and antigen reservoir and showed a particular autophagy, which efficiently promoted the activation of antigen presenting cells (APCs) and subsequent antigen cross-presentation. Such a “One but All” modality thus induced a high level of anti-tumor responses in a programmable way and resulted in efficient tumor regression in vivo. This work may shed light on the potential use of a new dimensional nano-platform in the development of high-performance cancer vaccines.Electronic supplementary information (ESI) available. See DOI: 10.1039/c5nr04986ePublication:Nanoscale, Volume 7, Issue 47, pp. 19949-19957 (2015).Pub Date:November 2015DOI:10.1039/c5nr04986eBibcode:2015Nanos…719949Y …719949Y/abstract
CN112220919 Nano coronavirus recombinant vaccine taking graphene oxide as carrier
AnmelderSHANGHAI NATIONAL ENGINEERING RESEARCH CENTER FOR NANOTECHNOLOGY CO., LTD.
上海纳米技术及应用国家工程研究中心有限公司
ErfinderCUI DAXIANG
崔大祥
GAO ANG
高昂
LIANG HUI
梁辉
TIAN JING
田静
LI XUELING
李雪玲
SHEN QI
沈琦
Vertreter上海东亚专利商标代理有限公司 31208
Titel(EN) Nano coronavirus recombinant vaccine taking graphene oxide as carrier
(ZH) 以氧化石墨烯为载体的纳米冠状病毒重组疫苗
Zusammenfassung(EN) The invention belongs to the field of nano materials and biological medicines, and relates to a vaccine, in particular to development of a 2019-nCoV coronavirus nuclear recombinant nano vaccine. The invention also comprises a preparation method of the vaccine and application of the vaccine in animal experiments. The novel coronavirus vaccine contains graphene oxide, carnosine, CpG and novel coronavirus RBD; The carnosine, the CpG and novel coronavirus RBD are combined on a framework of the graphene oxide; the coding sequence of the CpG is as shown in SEQ ID NO 1; and the novel coronavirus RBDrefers to that a novel coronavirus protein receptor binding region can generate a high-titer specific antibody aiming at the RBD in a mouse body, and strong support is provided for prevention and treatment of the novel coronavirus.
(ZH) 本发明属于纳米材料和生物医药领域，涉及一种疫苗，具体而言，涉及2019‑nCoV冠状病毒核重组纳米疫苗的开发。本发明还包括该疫苗的制备方法以及在动物试验中的应用。所述的新冠疫苗含有氧化石墨烯、肌肽、CpG、新冠病毒RBD；在氧化石墨烯的骨架上结合肌肽、CpG和新冠病毒RBD；所述的CpG的编码序列如SEQ ID NO 1所示；所述的新冠病毒RBD是指新型冠状病毒蛋白受体结合区域可以在小鼠体内产生高效价的针对RBD的特异性抗体，为新型冠状病毒的防治提供了强有力的支持。
Lethal Interactions of SARS-CoV-2 with Graphene Oxide: Implications for COVID-19 Treatment
- Masahiro Fukuda
- M. Saidul Islam
- Ryo Shimizu
- Hesham Nassar
- Nurun Nahar Rabin
- Yukie Takahashi
- Yoshihiro Sekine
- Leonard F. Lindoy
- Takaichi Fukuda*
- Terumasa Ikeda*
- Shinya Hayami*
Cite this: ACS Appl. Nano Mater. 2021, XXXX, XXX, XXX-XXXPublication Date:October 14, 2021https://doi.org/10.1021/acsanm.1c02446© 2021 American Chemical SocietyRIGHTS & PERMISSIONS
The rapid transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-driven infection signifies an ultimate challenge to global health, and the development of effective strategies for preventing and/or mitigating its effects are of the utmost importance. In the current study, an in-depth investigation for the understanding of the SARS-CoV-2 inactivation route using graphene oxide (GO) is presented. We focus on the antiviral effect of GO nanosheets on three SARS-CoV-2 strains: Wuhan, B.1.1.7 (U.K. variant), and P.1 (Brazilian variant). Plaque assay and real-time reverse transcription–polymerase chain reaction (RT-PCR) showed that 50 and 98% of the virus in a supernatant could be cleared following incubation with GO (100 μg/mL) for 1 and 60 min, respectively. Transmission electron microscopy (TEM) analysis and protein (spike (S) and nucleocapsid (N) proteins) decomposition evaluation confirm a two-step virus inactivation mechanism that includes (i) adsorption of the positively charged spike of SARS-CoV-2 on the negatively charged GO surface and (ii) neutralization/inactivation of the SARS-CoV-2 on the surface of GO through decomposition of the viral protein. As the interaction of S protein with human angiotensin-converting enzyme 2 (ACE2) is required for SARS-CoV-2 to enter into human cells, the damage to the S protein using GO makes it a potential candidate for use in contributing to the inhibition of the worldwide spread of SARS-CoV-2. Specifically, our findings provide the potential for the construction of an effective anti-SARS-CoV-2 face mask using a GO nanosheet, which could contribute greatly to preventing the spread of the virus. In addition, as the effect of surface contamination can be severe in the spreading of SARS-CoV-2, the development of efficient anti-SARS-CoV-2 protective surfaces/coatings based on GO nanosheets could play a significant role in controlling the spread of the virus through the utilization of GO-based nonwoven cloths, filters, and so on.
Japan finds black particles in Moderna vaccine Published1 SeptemberShare Japan has put a batch of Moderna’s Covid-19 vaccine on hold after a foreign substance was found in a vial.
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