NIH: “Characteristics of Antiviral Agents That Are Approved or Under Evaluation for the Treatment of COVID-19”
RE: Ivermectin <Some have reported that there has been a “silent” update made to this key NIH website. I cannot personally verify this.>
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NIH: “The dose most commonly used in clinical trials is IVM 0.2–0.6 mg/kg PO given as a single dose or as a once-daily dose for up to 5 days.” Roger that?
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Most serious side effects- “Neurological AEs have been reported when IVM has been used to treat parasitic diseases, but it is not clear whether these AEs were caused by IVM or the underlying conditions.”
https://www.covid19treatmentguidelines.nih.gov/tables/table-2e/
READ https://www.dsalud.com/revistas/numero-170-abril-2014/cartas-al-director https://www.dsalud.com/revistas/numero-116-mayo-2009/cartas-al-director
Marvel star Evangeline Lilly protests COVID-19 vaccine mandates: ‘I am still pro choice’ CHARLES TREPANY | USA TODAY | 17 hours ago https://www.usatoday.com/story/entertainment/celebrities/2022/01/27/marvel-evangeline-lilly-protests-covid-vaccine-mandate/9249232002/
- Evangeline Lilly is speaking out against COVID-19 vaccine mandates on social media.
- The “Ant-Man and the Wasp” star shared she attended a protest “to support bodily sovereignty” over the weekend.
- “This is not the way,” the Marvel star wrote. “This is not love.”
- In March 2020, Lilly sparked controversy when she downplayed COVID-19 as both a “respiratory flu” and a possible political ploy.
Trimetoprim-sulfametoxazol (Bactrim) y nitrofurantoína (Macrobid). Ciertos medicamentos para las infecciones urinarias pueden aumentar el riesgo de defectos de nacimiento, advierten los funcionarios
(Certain UTI medications may raise risk of birth defects, officials warn)
CBS News, 13 de enero de 2018
http://5newsonline.com/2018/01/13/certain-uti-medications-may-raise-risk-of-birth-defects-officials-warn/
Traducido por Salud y Fármacos https://www.saludyfarmacos.org/lang/es/boletin-farmacos/boletines/ago201801/09_tri/
https://biblearchaeologyreport.com/
Helicobacter pylori: A Beneficial Gastric Pathogen?
Amin Talebi Bezmin Abadi Additional article information Introduction Since Helicobacter pylori (H. pylori) is the first successful culture three decades ago, ongoing perspectives regarding the relationship between the bacterium and human health have changed radically (1, 2). Apart from tremendous studies performed during the last years, there are still many debates regarding the unclear rationale for existence of such bacteria in human stomach (3, 4). Basically, due to the beneficiary effects of H. pylori colonization (regression in child asthma and other allergic disorders), it has been concluded that H. pylori is a common flora or at least harmless bacterium (5–10), Conversely, because of the causative role of H. pylori in certain digestive diseases such as duodenal ulcer and gastric cancer, other reports are quite contradictory (11–13). A large number of discussions led to a consensus regarding presence of H. pylori in the human stomach (5, 11, 14, 15). Our knowledge about biology of H. pylori suggests that the bacterium is highly adapted to stay in gastric mucosa for long time (1, 16). Indeed, living in lower surface of gastric mucosa, with no bacterial competition, provided a novel place to survive. Moreover, H. pylori is able to multiply freely due to the protective effects by mucosal layer. Thus, H. pylori had an opportunity to thrive in stomach over the course of tens of thousands of years of co-evolution with humans (17). Additionally, the high frequency of mutation in the genome also led to higher chances of survival, and natural selection helped them to remain and cause chronic infection (18). Determining whether H. pylori is beneficial or detrimental in human stomach has been a challenging area of research in gastroenterology (5, 11, 19, 20). In this article, we aim to elucidate various aspects of this persistent colonization of this beneficial infection.
GERD and H. pylori: A good example of beneficial effects Gastroesophageal reflux disease (GERD) incidence has been increased mostly in developed communities where H. pylori infection is almost effectively eradicated (27, 28). GERD is the main risk factor for Barrett’s esophagus, and it has been associated with another deadly gastroduodenal carcinoma called “esophageal adenocarcinoma” (3, 5). However, the relationship between GERD and H. pylori remains incompletely defined (29). Several studies suggested that eradication of H. pylori infection in the setting of duodenal ulcer disease would result in an increase in GERD symptoms (3, 30). In other words, an inverse association of H. pylori infection with decreased rate of this sort of disease was a challenging topic in new gastroenterology (14, 31–33). Of note, GERD and its sequelae, which include Barrett’s esophagus and esophageal adenocarcinoma, is decreasing in countries in which most individuals are infected by H. pylori (15, 34, 35). Actually, not only has worldwide H. pylori prevalence changed in recent decades but also other environmental factors affecting on human health such as socioeconomical levels, diet, and vaccination were drastically changed (10, 17). If so, H. pylori is confronting with different situation rather than before. Remarkably, H. pylori can undergo drastic genetic change through each generation, while human genes do not change frequently. As a result, frequent genetic changes in H. pylori helped the bacterium to adapt quickly (18). Remarkably, slower adaptation in humans deteriorates longtime established equilibrium between H. pylori and human. Because of this, elimination of H. pylori as permanent resident of human microbiome would not be the first option to deal with gastroduodenal diseases. According to what explained about GERD and H. pylori as a protective effect, the long cohabitation in our stomach calls for more deep studies to elucidate microbiota and human health. GERD is the best example of disease, which became more frequent after starting the H. pylori treatment (34). Indeed, after antibiotic usage against H. pylori and, of course, its eradication in Western countries, a constant equilibrium between H. pylori and human health disappeared. Interestingly, in Northeastern Malaysia, the low prevalence of H. pylori infection was frequently reported (36–38). As general rule, one expects that frequency of diseases such as asthma and GERD should be relatively low rather than the findings of expected inverse association were not found (39–41). Actually, the association between H. pylori infection and certain diseases such as GERD and asthma risk can be affected by geographical and genetic differences (37, 41). As a result, there is a complex and mostly undetermined associations between human microbiome and health; accordingly, all attempts to change this arranged biological system can exacerbate certain diseases. Undoubtedly, we need to eradicate virulent H. pylori in people with adverse clinical manifestations, but this conclusion cannot be generalized to all H. pylori positive subjects. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291894/
The mortality rate related to H pylori infection is not precisely known, but it seems to be minimal (ie, approximately 2%-4% of all infected people). Mortality is due to the complications of the infection, such as gastric ulcer perforation or MALTomas of the GI tract.https://www.medscape.com › answers What is the mortality rate for Helicobacter pylori (H … – Medscape
For most people the infection won’t cause them any problems. But in some, H. pylori can cause long-lasting irritation, swelling and pain in the stomach (known as ‘severe chronic atrophic gastritis’ or SCAG) and stomach ulcers. This can lead to cancer.6 sept 2021https://www.cancerresearchuk.org › … Does H.pylori cause cancer?
Se denomina cámara Kirlian a una cámara capaz de plasmar en una imagen el efecto corona de cualquier objeto u organismo al aplicar un campo eléctrico sobre una placa. La fotografía Kirlian está directamente relacionada con el fenómeno eléctrico de los fuegos de san Telmo. Se ha demostrado que la fotografía Kirlian solo indica variaciones de presión, humedad, contacto a tierra y conductividad. La descarga de corona es un fenómeno bien conocido que se explica en física elemental.
Research note: Although copper does have anti-inflammatory properties and has shown benefit for reducing heart disease and Alzheimer’s disease, there currently is no research to support dietary copper or supplements as a treatment for arthritis.https://www.arthritis.org › treatment Vitamin and Mineral Guide for Arthritis
Some people spread pathogens less than others perhaps because of their immune system
1°entrevista al Dr. Stefan Lanka por Mark Pfister – ¿Cuáles Virus? – COMPLETO en ESPAÑOL 201810 oct El Dr Stefan Lanka, micro-biólogo, nos habla de la realidad de las investigaciones científicas inherentes a la presunta existencia de los virus. ¿Científico? ¿Qué quiere decir? ¿Cuáles son las bases de los conocimientos científicos disponibles en medicina? ¿En qué se basan? ¿Ciencia o negocios? Este video fue presentado al Congreso Open Day de nuestra Escuela de Formación Profesional sobre las 5LB con el tema: “los fundamentos. la validez y los límites de los conocimientos médicos-científicos”. www.5lbtraining.com
Risk of myocarditis following sequential COVID-19 vaccinations by age and sex
Martina Patone, Xue W Mei, Lahiru Handunnetthi, Sharon Dixon, Francesco Zaccardi, Manu Shankar-Hari, Peter Watkinson, Kamlesh Khunti, Anthony Harnden, Carol AC Coupland, Keith M. Channon, View ORCID ProfileNicholas L Mills, Aziz Sheikh, Julia Hippisley-Coxdoi: https://doi.org/10.1101/2021.12.23.21268276This article is a preprint and has not been peer-reviewed [what does this mean?]. It reports new medical research that has yet to be evaluated and so should not be used to guide clinical practice. In an updated self-controlled case series analysis of 42,200,614 people aged 13 years or more, we evaluate the association between COVID-19 vaccination and myocarditis, stratified by age and sex, including 10,978,507 people receiving a third vaccine dose. Myocarditis risk was increased during 1-28 days following a third dose of BNT162b2 (IRR 2.02, 95%CI 1.40, 2.91). Associations were strongest in males younger than 40 years for all vaccine types with an additional 3 (95%CI 1, 5) and 12 (95% CI 1,17) events per million estimated in the 1-28 days following a first dose of BNT162b2 and mRNA-1273, respectively; 14 (95%CI 8, 17), 12 (95%CI 1, 7) and 101 (95%CI 95, 104) additional events following a second dose of ChAdOx1, BNT162b2 and mRNA-1273, respectively; and 13 (95%CI 7, 15) additional events following a third dose of BNT162b2, compared with 7 (95%CI 2, 11) additional events following COVID-19 infection. An association between COVID-19 infection and myocarditis was observed in all ages for both sexes but was substantially higher in those older than 40 years. These findings have important implications for public health and vaccination policy. Funding Health Data Research UK. https://www.medrxiv.org/content/10.1101/2021.12.23.21268276v1
Generalmente, las principales agencias sanitarias del mundo reconocen a las diluciones de peróxido de hidrógeno de hasta 6 % como seguras para su uso como agente antimicrobiano, agente oxidante[10][11] y otros propósitos. Debido a su efecto oxidante, desde hace muchos años se ha utilizado como agente antiséptico y antibacteriano. Su uso ha descendido los últimos años debido a la popularidad de otros productos sustitutivos. Todavía se utiliza en muchos hospitales, centros médicos y clínicas.
- D. González, I. Bejarano, C. Barriga, A.B. Rodríguez, J.A. Pariente (2010). “Oxidative Stress-Induced Caspases are Regulated in Human Myeloid HL-60 Cells by Calcium Signal“. Current Signal Transduction Therapy 5: 181-186. doi:[10.2174/157436210791112172]
- ↑ Bejarano I, Espino J, González-Flores D, Casado JG, Redondo PC, Rosado JA, Barriga C, Pariente JA, Rodríguez AB (2009). “Role of Calcium Signals on Hydrogen Peroxide-Induced Apoptosis in Human Myeloid HL-60 Cells“. International Journal of Biomedical science 5(3): 246-256.
REVIEW La cura en un minuto. El secreto para curar prácticamente todas las enfermedades. Madison cavanaugh
New study focuses on growing enzymes on International Space Station to help develop nerve agent antidotes https://homelandprepnews.com/stories/23315-new-study-focuses-growing-enzymes-international-space-station-help-develop-nerve-agent-antidotes/?amp
The International Space Station’s (ISS) microgravity environment could provide a means of improving the understanding of toxic nerve agents, such as sarin and VX, and how to combat them, according to a researchers from the National Institutes of Health (NIH)-supported Countermeasures Against Chemical Threats (CounterACT) project.
The project centers on the study of organophosphates (OPs), a family chemicals that work to block the enzyme acetylcholinesterase (AChE). AChE is important for the body’s ability to allow muscles to relax after nervous system stimulation. When this enzyme is blocked by OPs such as sarin or VX, muscles cannot relax and the resulting condition leads to paralysis and potential death.
According to NIH, developing antidotes to OP poisoning requires detailed knowledge about the structure of AChE, however, the forces of Earth’s gravity have posed challenges to that area of research. This fact led researchers to send human AChE samples to ISS in June in order to grow large crystals of pure enzyme to a size not achievable on earth due to gravitational interference.
“By taking advantage of the microgravity conditions of the International Space Station, we hope to grow better, more uniform crystals that we are unable to grow on Earth,” Andrey Kovalevsky of the Oak Ridge National Laboratory said.
Once the enzyme crystals grow to a large enough size, the samples will be flown back down to earth to be analyzed via a method called neutron diffraction, which will provide an atomic-level view of the enzymes.
University of California-San Diego (UCSD) researcher Zoran Radić said the technique would enable researchers to get a closer look at how the enzyme interacts with pesticides and nerve agents and learn about how the bond between the two can be chemically reversed.
Contemporary countermeasures to OP exposure work by reactivating AChE by breaking its chemical bond with OP, however, the speed in which they become effective is too slow.
NIH said in a release that the project will help researchers develop antidotes that break the AChE-OP bond more quickly and can be delivered orally, which is key when dealing with large-scale exposure to nerve poisons.
Contributions to the project have been made by the National Institute of Neurological Disorders and Stroke (NINDS), the Oak Ridge National Laboratory, UCSD, the University of Utah, and the NIH Office of the Director.
PUBLISHED BYHPN News Desk5 YEARS AGO
Masaje, moxibustion
9 venenos que curan La biomedicina busca en las sustancias tóxicas fabricadas por animales el remedio contra decenas de enfermedades. Usadas en pequeñas dosis, pueden combatir el cáncer, el dolor, el alzhéimer… https://www.muyinteresante.es/naturaleza/fotos/9-venenos-que-curan
La extraordinaria historia del hombre que se inyecta veneno letal de serpiente pero no se muere Redacción BBC Mundo 20 marzo 2017 https://www.bbc.com/mundo/noticias-39331284
“Mi sangre es única porque llevo casi 30 años haciendo esto”, dice el entusiasta de las serpientes.
La exposición gradual de Steve al veneno de serpiente ha funcionado de la misma manera que las vacunas funcionan para la mayoría de nosotros, explica la doctora Weston.
Por qué el veneno es una de las sustancias más útiles de la naturaleza Jonathan Amos Corresponsal de Ciencia de BBC 31 octubre 2017 “Sin veneno estaríamos acabados”, dice el experto del Museo de Historia Natural de Londres, Ronald Jenner https://www.bbc.com/mundo/noticias-41819393
“Si comes frutas, estas están polinizadas por abejas, que son venenosas”, dice Ronald Jenner, experto en evolución del veneno del NHM.
“Los higos están polinizados por avispas parasitoides. Si comes calamares o pulpos, son venenosos”.
“Los venenos se usan en cosméticos: las máscaras para la cara usan una versión sintética del péptido de víbora que relaja los músculos”, añade el científico.
“Y puede que no lo sepas, pero tu remedio para la diabetes es probablemente un versión sintética de una toxina”.
El veneno del murciélago vampiro hace que la sangre de la presa continúe fluyendo.
También el vino tiene veneno.
“El vino tinto que bebes fue aclarado con las vejigas natatorias de un bagre venenoso. No lo ponen en la etiqueta, pero los tentáculos del veneno están por todas partes en tu vida diaria”, dice Jenner.
“La ropa de algodón que usas… La única razón por la que podemos cultivar algodón en grandes monocultivos es porque las avispas parasitoides eliminan a los insectos que chupan la savia que, de otro modo, dañarían las cosechas. Sin veneno, estaríamos acabados“.
Algunos venenos espesan la sangre para producir coágulos en la víctima, lo que a su vez provoca un derrame y una muerte rápida.
Algunos venenos actúan como agentes anticoagulantes. Los murciélagos vampiro usan esta estrategia para poder seguir chupando sangre de una herida.
El ejemplo más famoso es probablemente el del Bothrops jararaca, una serpiente brasileña que puede rápidamente hacer que le baje la presión a su víctima para que se desmaye y caiga al suelo.
Este veneno les mostró a los científicos el camino para crear uno de las primeros tratamientos para la presión alta en seres humanos.
Después está también el “monstruo de Gila”. La picadura dolorosa de este lagarto incorpora un péptido que regula la glucosa.
AstraZeneca comercializa una droga basada en esta molécula llamada Exenatide que se utiliza para controlar la diabetes tipo 2. Su costo es de cientos de millones al año.
WHO: Healthy people still don’t need to wear masks for coronavirus protection, but that guidance could change Anna Medaris Miller Apr 1, 2020, 1:59 PM https://www.businessinsider.com/who-healthy-people-dont-need-medical-masks-that-could-change-2020-4
While he acknowledged there’s debate about whether healthy members of the community should wear masks, Tedros said the WHO recommends medical masks “for people who are sick and those caring for them,” along with other protective measures.
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