Their findings, which have recently been published in PNAS, reveal that higher body temperatures drive the activity of certain proteins that, in turn, switch genes responsible for the body’s immune response on and off, as required.
Temperature regulates NF-κB dynamics and function through timing of A20 transcription
C. V. Harper, D. J. Woodcock, C. Lam, M. Garcia-Albornoz, View ORCID Profile A. Adamson, L. Ashall, W. Rowe, P. Downton, L. Schmidt, S. West, D. G. Spiller, D. A. Rand, and View ORCID Profile M. R. H. White
See all authors and affiliationsPNAS May 29, 2018 115 (22) E5243-E5249; first published May 14, 2018; https://doi.org/10.1073/pnas.1803609115
- Edited by Ronald N. Germain, National Institutes of Health, Bethesda, MD, and approved April 27, 2018 (received for review March 7, 2018)
Significance Inflammation is often accompanied by temperature change, but little is known about the role of temperature in the inflammatory response. We show that physiologically relevant temperature changes significantly perturb NF-κB dynamics following TNFα stimulation in single cells. Using experimentation informed by mathematical modeling, we found that these changes were mediated, at least in part, through the key feedback gene TNFAIP3/A20. Curtailing A20 expression removed temperature sensitivity across the fever range (37 °C to 40 °C). Gene expression was generally unaffected between these temperatures, although a select set of NF-κB−regulated genes was up-regulated at early time points. These genes were predominantly involved in inflammation, signaling, and cell fate. The cellular response to inflammation may therefore be mechanistically and functionally regulated by temperature.
Abstract NF-κB signaling plays a pivotal role in control of the inflammatory response. We investigated how the dynamics and function of NF-κB were affected by temperature within the mammalian physiological range (34 °C to 40 °C). An increase in temperature led to an increase in NF-κB nuclear/cytoplasmic oscillation frequency following Tumor Necrosis Factor alpha (TNFα) stimulation. Mathematical modeling suggested that this temperature sensitivity might be due to an A20-dependent mechanism, and A20 silencing removed the sensitivity to increased temperature. The timing of the early response of a key set of NF-κB target genes showed strong temperature dependence. The cytokine-induced expression of many (but not all) later genes was insensitive to temperature change (suggesting that they might be functionally temperature-compensated). Moreover, a set of temperature- and TNFα-regulated genes were implicated in NF-κB cross-talk with key cell-fate–controlling pathways. In conclusion, NF-κB dynamics and target gene expression are modulated by temperature and can accurately transmit multidimensional information to control inflammation.
https://www.pnas.org/content/115/22/E5243
Vitamin C and Immune Function Anitra C. Carr and Silvia Maggini Additional article information Abstract Vitamin C is an essential micronutrient for humans, with pleiotropic functions related to its ability to donate electrons. It is a potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes. Vitamin C contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune system. Vitamin C supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, thereby potentially protecting against environmental oxidative stress. Vitamin C accumulates in phagocytic cells, such as neutrophils, and can enhance chemotaxis, phagocytosis, generation of reactive oxygen species, and ultimately microbial killing. It is also needed for apoptosis and clearance of the spent neutrophils from sites of infection by macrophages, thereby decreasing necrosis/NETosis and potential tissue damage. The role of vitamin C in lymphocytes is less clear, but it has been shown to enhance differentiation and proliferation of B- and T-cells, likely due to its gene regulating effects. Vitamin C deficiency results in impaired immunity and higher susceptibility to infections. In turn, infections significantly impact on vitamin C levels due to enhanced inflammation and metabolic requirements. Furthermore, supplementation with vitamin C appears to be able to both prevent and treat respiratory and systemic infections. Prophylactic prevention of infection requires dietary vitamin C intakes that provide at least adequate, if not saturating plasma levels (i.e., 100–200 mg/day), which optimize cell and tissue levels. In contrast, treatment of established infections requires significantly higher (gram) doses of the vitamin to compensate for the increased inflammatory response and metabolic demand.Keywords: ascorbate, ascorbic acid, immunity, immune system, neutrophil function, microbial killing, lymphocytes, infection, vitamin C https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707683/
Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies? Oxid Med Cell Longev. 2017;2017:4234765. doi: 10.1155/2017/4234765. Epub 2017 Jul 2. PMID: 28751932; PMCID: PMC5511671.
Highlights:
- Moderate intensity aerobic exercise training or regular physical activity is beneficial for immune function.
- For example, some evidence shows that individuals with an active lifestyle exhibit stronger immune responses to vaccination compared to those who are inactive. Encouragingly, poor vaccine responses, which are characteristic of an aging immune system, can be improved by single or repeated bouts of exercise (by association, exercise will also improve the immune system overall).
- In addition, exercise-induced lymphocytosis, and the subsequent lymphocytopenia, is thought to facilitate immune surveillance, whereby lymphocytes search tissues for antigens derived from viruses, bacteria, or malignant transformation.
- Aerobic exercise training is anti-inflammatory and is linked to lower morbidity and mortality from diseases with infectious, immunological, and inflammatory etiologies, including cancer.
- These observations have led to the view that aerobic exercise training might counter the age-associated decline in immune function, referred to as immunosenescence.
- This article summarizes the aspects of immune function that are sensitive to exercise-induced change, highlighting the observations which have stimulated the idea that aerobic exercise training could prevent, limit, or delay immunosenescence, perhaps even restoring aged immune profiles.
- These potential exercise-induced anti-immunosenescence effects might contribute to the mechanisms by which active lifestyles reduce the risk of developing cancer and perhaps benefit patients undergoing cancer therapy.
https://www.hindawi.com/journals/omcl/2017/4234765/
Hindawi is a commercial publisher of scientific, technical, and medical (STM) literature. Founded in 1997, it currently publishes more than 230 peer-reviewedscientific journals as well as a number of scholarly monographs, with an annual output of roughly 20,000 articles each year.[3][4] In 2021, Hindawi was purchased by John Wiley & Sons.[5]
- based on projections from the first 8 months of 2011
- ^ “A 2018 update on Hindawis Corporate Structure”. about.hindawi.com. 2018-03-14. Retrieved 2019-04-02.
- ^ “Meet the Team”. about.hindawi.com. 2018-08-05. Retrieved 2019-04-02.
- ^ “About Hindawi”. about.hindawi.com. Retrieved 2018-11-18.
- ^ “Books”. Hindawi. Retrieved 3 April 2019.
- ^ a b “Wiley Announces the Acquisition of Hindawi”. 2021-01-05.
Pope: Solo para usuarios registrados
Federal: Solo para usuarios registrados
Camu camu: todos los beneficios de la ‘superfruta’ con más vitamina C El camu camu es el alimento con más vitamina C, pero esta no es su única propiedad: está lleno de antioxidantes, minerales e incluso ayuda a adelgazar. 26 noviembre, 2020 17:06 Marta Corral @MartinhaCorral El fruto del Myrciaria dubia, nombre científico del arbusto nativo de la Amazonia que crece en Perú, Colombia y Brasil, contiene además otros fitocomponentes que lo consolidan como un poderoso antioxidante con propiedades muy beneficiosas para nuestro organismo. https://www.elespanol.com/ciencia/nutricion/20201126/camu-camu-beneficios-superfruta-vitamina/530197400_0.html
Malpighia emarginata, llamada comúnmente acerola, cerecita, manzanita o semeruco, nombre que recibe su fruto, es una especie de la familia semeruco que crece espontáneamente en América Central, las Antillas y en las zonas tropicales húmedas de Sudamérica.
| Acerola |
|---|
El gubinge, kakadu o murunga (Terminalia ferdinandiana), es una planta con flores de la familia Combretaceae, nativa de Australia, muy expandida en las planicies tropicales del noroccidente de Australia hasta el este de Arnhem. Su fruto tiene la concentración más alta de vitamina C.[1]
[1] «Bush Book Volume 2, Chapter 3: Food and Nutrition». Archivado desde el original el 19 de agosto de 2016. Consultado el 10 de noviembre de 2013.
Es muy notable su enorme cantidad de vitamina C ya que posee alrededor de 3150 mg / 100 g
Scottish man Angus Barbieri (1939 – 7 September 1990) fasted for 382 days, from June 1965 to July 1966. He lived on tea, coffee, soda water, and vitamins while living at home in Tayport, Scotland, and frequently visiting Maryfield Hospital for medical evaluation. He lost 276 pounds (125 kg) and set a record for the length of a fast.[1]
[1] Stewart, W. K.; Fleming, Laura W. (March 1973). “Features of a successful therapeutic fast of 382 days’ duration”. Postgraduate Medical Journal. 49 (569): 203–209. doi:10.1136/pgmj.49.569.203. PMC2495396. PMID4803438.
El gobierno de Serbia defendió a Novak Djokovic y le envió un dardo a Australia: “La farsa ha terminado” Funcionarios del país europeo se expresaron a favor del tenista y destacaron que el deportista “fue maltratado”. Los detalles 16 de Enero de 2022 “La farsa ha terminado. La política ha derrotado al deporte esta vez”, lamentó la Federación de Tenis de Serbia en un comunicado, tras conocerse el fallo que confirmó la expulsión del jugador. Vucic fue el primero en defender al número 1 del mundo al considerar que Australia “se está humillando a sí misma” y el fallo del Tribunal Federal pone fin a días de “maltrato” recibido por el nueve veces campeón en Melbourne. https://www.infobae.com/america/deportes/2022/01/16/el-gobierno-de-serbia-defendio-a-novak-djokovic-y-le-envio-un-dardo-a-australia-la-farsa-ha-terminado/
Vucic: Australia “se humilló a sí misma” por caso Djokovic hace 12 horas https://m.dw.com/es/vucic-australia-se-humill%C3%B3-a-s%C3%AD-misma-por-caso-djokovic/a-60440584
[Robert Malone] Some of my papers and other patents on this subject area (1988-2000)
- A novel approach to study packaging of retroviral RNA by RNA transfection (Abstract). RW Malone, P. Felgner, I. Verma. RNA Tumor Viruses, May 17-18, 1988. Cold Spring Harbor (the first in a series of papers/abstracts on RNA transfection).
- mRNA Transfection of cultured eukaryotic cells and embryos using cationic liposomes. Malone RW. Focus. 1989; 11:61-8
- The SALK patent that was filed with the USPTO on 3/21/1989. Note that the cover letter hides this – and says it was filed on 3/29/89 – the sane date as all the VICAL patents, showing that there was collusion. WRITTEN BT ME IN 1988.
- THE VERY FIRST mRNA VACCINE EXPERIMENTAL DATA 1990 (from Vical to patent office)
- Cationic liposome-mediated RNA transfection. Malone RW, Felgner PL, Verma IM. Proc Natl Acad Sci (PNAS) U S A. 1989;86(16):6077-81. Cited in 749 articles.
- Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles. Note that Robert was a student at Northwestern, and was never affiliated with University of Wisc.
- High levels of messenger RNA expression following cationic liposome mediated transfection tissue cultured cells. Malone R, Kumar R, Felgner P. NIH Conference: “Self-Cleaving RNA as an Anti-HIV Agent (abstract). Washington, DC June 1989.
- Cationic liposome-mediated RNA transfection. Dwarki VJ, Malone RW, Verma IM. Methods Enzymol. 1993;217:644-54. Cited in: 102 articles. Cationic liposome-mediated RNA transfection V J Dwarki et al. Methods Enzymol. 1993. Methods Enzymol. 1993;217:644-54.doi: 10.1016/0076-6879(93)17093-k. V J Dwarki 1, R W Malone, I M Verma Affiliation 1Vical Inc., San Diego, California 92121. PMID: 7682647 DOI: 10.1016/0076-6879(93)17093-k
- Delivery of exogenous DNA (includes mRNA) sequences in a mammal P Felgner, JA Wolff, GH Rhodes, R Malone, D Carson. Biotechnology Advances 1993: 15 (3-4), 763-763
Patents and papers – from the 1990s
- DNA vaccines for eliciting a mucosal immune response (includes mRNA). US Pat. Ser. No. 6,110,898. Inventors: RW Malone and Jill Glasspool Malone. Date of issue: 8/29/00. Cited in 40 articles. Priority Date: 1996.
- Formulations and methods for generating active cytofectin: polynucleotide transfection complexes. Robert W Malone, et al. US Pat. Ser. No. 5,925,623 7/20/99.
- Cationic Transport Reagents. US Pat. Ser. No. 5,892,071 Robert W Malone, et. al. issued 4/06/99.
- Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin: polynucleotide transfection complexes. Robert W Malone, et. al. US Pat. Ser. No. 5,824,812 issued 10/20/98.
- Cationic Transport Reagents. Robert W Malone, et. al. US Pat. Ser. No. 5,744,625 issued 4/28/98.
- Cationic Transport Reagents. Robert W Malone, et. al. US Pat. Ser. No. 5,527,928, date of issue: 6/18/96.
- Marked enhancement of macaque respiratory tissue transfection by aurintricarboxylic acid. Glasspool-Malone J, …, Malone RW. Gene Med. 2002;4(3):323-2.
- Enhancing direct in vivo transfection with nuclease inhibitors and pulsed electrical fields. Glasspool-Malone J, Malone RW. In Gene Therapy Methods: Methods Enzymol. 2002;346:72-91
- Cutaneous transfection and immune responses to intradermal nucleic acid vaccination are significantly enhanced by in vivo electropermeabilization. Drabick JJ, Glasspool-Malone J, …, Malone RW. Mol Ther. 2001;3(2):249-55. Cited in 192 articles.
- Theory and in vivo application of electroporative gene delivery. Somiari S, Glasspool-Malone J, … Malone RW. Mol Ther. 2000;2(3):178-87. Cited in 345 articles.
- Efficient nonviral cutaneous transfection. Glasspool-Malone J, …, Malone RW. Mol Ther. 2000;2(2):140-6. Cited in 138 articles.
- Developing dendritic cell polynucleotide vaccination for prostate cancer immunotherapy. Berlyn KA, …, Malone RW J Biotechnol. 1999;73(2-3):155-79
- Models of Cationic Liposome Mediated Transfection. Gene Therapy and Molecular Biology. Ahearn A, Malone RW. Vol 4. Gene Therapy and Molecular Biology 1999;4
- Cationic lipid-mediated gene delivery to murine lung: correlation of lipid hydration with in vivo transfection activity. Bennett MJ, …, Malone RW, Nantz MH. J Med Chem. 1997;40(25):4069-78
- Considerations for the design of improved cationic amphiphile-based transfection reagents. Bennett MJ, …, Malone RW. Journal of Liposome Research 1996;6(3):545-65
- Structural and functional analysis of cationic transfection lipids: the hydrophobic domain. Balasubramaniam RP, …, Malone RW. Gene Ther. 1996;3(2):163-72. cited in 172 articles.
- A flexible approach to synthetic lipid ammonium salts for polynucleotide transfection. MJ Bennett, RW Malone, MH Nantz. Tetrahedron letters 36 (13), 2207-2210
For the written history of the early events, by Dr. Jill Glasspool Malone
270 mixed signatories. we have over 16,000 signatories for our declaration and they are physicians and medical scientist professionals. this is a list of collaborators in creation of the mass formation process. remember their names. Eric Topol is prominent. these people want more censorship https://spotifyopenletter.wordpress.com/2022/01/10/an-open-letter-to-spotify/
Pope Francis is pro-Pfizer https://www.ncregister.com/blog/pfizer-and-the-vatican
Under the right circumstances, 10 to 15 minutes of sun on the arms and legs a few times a week can generate nearly all the vitamin D we need.1 sept 2008https://www.health.harvard.edu › ti… Time for more vitamin D – Harvard Health
If sun exposure produces slight pinkness, the amount of vitamin D produced in response to exposure of the full body is equivalent to ingesting 10,000-25,000 IU. A variety of factors reduce the skin’s vitamin D-3 production, including increased skin pigmentation, aging, and the topical application of a sunscreen.https://www.medscape.com › answers What is the recommended sun exposure for production of vitamin …
READ hipervitaminosis
Associations have been shown between vitamin D levels and several respiratory tract infections suggesting that vitamin D deficiency may predispose to infection. Outbreaks of respiratory infections occur predominantly during months associated with lower exposure to the sun. The Institute of Medicine concluded in a 2011 report that the existing data were “not consistently supportive of a causal role” for vitamin D in reducing the risk of infection. Other studies suggest that vitamin D supplementation can provide a protective role in reducing the incidence or severity of respiratory infections.[1][2]
Vitamin D has long been associated with tuberculosis.[3][4] Beneficial effects in COPD have also been shown.[5]
- Martineau AR, Jolliffe DA, Greenberg L, Aloia JF, Bergman P, Dubnov-Raz G, et al. (January 2019). “Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis”. Health Technology Assessment. 23 (2): 1–44. doi:10.3310/hta23020. PMC 6369419. PMID 30675873.
- ^ Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. (February 2017). “Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data”. BMJ. 356: i6583. doi:10.1136/bmj.i6583. PMC 5310969. PMID 28202713.
- ^ Luong K, Nguyen LT (June 2011). “Impact of vitamin D in the treatment of tuberculosis”. The American Journal of the Medical Sciences. 341 (6): 493–8. doi:10.1097/MAJ.0b013e3182070f47. PMID 21289501. S2CID 18802134.
- ^ Nnoaham KE, Clarke A (February 2008). “Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis”. International Journal of Epidemiology. 37 (1): 113–9. CiteSeerX 10.1.1.513.3969. doi:10.1093/ije/dym247. PMID 18245055.
- ^ Jolliffe DA, Greenberg L, Hooper RL, Mathyssen C, Rafiq R, de Jongh RT, Camargo CA, Griffiths CJ, Janssens W, Martineau AR (April 2019). “Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials”. Thorax. 74 (4): 337–345. doi:10.1136/thoraxjnl-2018-212092. PMID 30630893.
Overall, there was a significant beneficial effect of vitamin D supplementation in decreasing the risk of experiencing at least one acute respiratory tract infection (OR 0.88; 95% CI: 0.81, 0.96; P=0.003).https://www.who.int › commentary WHO | Vitamin D for prevention of respiratory tract infections
Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Front Public Health. 2021 Dec 22;9:736665. doi: 10.3389/fpubh.2021.736665. PMID: 35004568; PMCID: PMC8727532.
Highlights:
- The aim of the present meta-analysis was to investigate whether vitamin D status is associated with the COVID-19 severity, defined as ARDS requiring admission to intensive care unit (ICU) or mortality (primary endpoints) and with the susceptibility to SARS-CoV-2 and COVID-19-related hospitalization (secondary endpoints).
- Methods: A search in PubMed, ScienceDirect, Web of Science, Google Scholar, Scopus, and preprints repositories was performed until March 31th 2021 to identify all original observational studies reporting association measures, or enough data to calculate them, between Vitamin D status (insufficiency <75, deficiency <50, or severe deficiency <25 nmol/L) and risk of SARS-CoV-2 infection, COVID-19 hospitalization, ICU admission, or death during COVID-19 hospitalization.
- Fifty-four studies (49 as fully-printed and 5 as pre-print publications) were included for a total of 1,403,715 individuals.
- The association between vitamin D status and SARS-CoV2 infection, COVID-19 related hospitalization, COVID-19 related ICU admission, and COVID-19 related mortality was reported in 17, 9, 27, and 35 studies, respectively.
- Severe deficiency, deficiency and insufficiency of vitamin D were all associated with ICU admission SARS-CoV-2 infection and COVID-19 hospitalization.
- Considering specific subgroups (i.e., Caucasian patients, high quality studies, and studies reporting adjusted association estimates) the results of primary endpoints did not change.
- Interpretations: Patients with low vitamin D levels present an increased risk of ARDS (COVID-19 severity) requiring admission to intensive care unit (ICU) or mortality due to SARS-CoV-2 infection and a higher susceptibility to SARS-CoV-2 infection and related hospitalization.
https://www.frontiersin.org/articles/10.3389/fpubh.2021.736665/full
¿Qué es la hipercapnia? La hipercapnia se produce cuando hay demasiado dióxido de carbono (CO2) en el torrente sanguíneo. Por lo general, ocurre como resultado de la hipoventilación o de no poder respirar adecuadamente y llevar oxígeno a los pulmones.https://www.healthline.com › health Hipercapnia: Qué es, causas y tratamiento – Healthline
Facemasks Are Not a Mere “Inconvenience”
BY AARON HERTZBERG DECEMBER 27, 2021 MASKS 17 MINUTE READ https://brownstone.org/articles/facemasks-are-not-a-mere-inconvenience/
So what exactly is the big deal about wearing masks?
In a nutshell – as was just stated – mask wearing is to many people something that is enormously stressful, and something that evokes inordinately powerful negative emotions. This is simply the reality, irrespective of whether such feelings “make sense”.
The following list is not exhaustive, just a collection of some of the factors that make mask wearing, especially forced masking, so distressing to many people.
A few important things to keep in mind:
- Not every listed issue is true for every person who finds masks distressing.
- Each issue amplifies the other ones, so that the cumulative distress is far greater than the sum of its parts. It’s like the difference between 1+2+3+…10 and 1x2x3x…10 (55 vs 3,628,800).
- This list is not exhaustive.
- The short explanations are intended to give a bit more insight into how people might typically experience that particular stress. They are not intended to comprehensively define the issue.
A Sense of Helplessness
Being at the mercy of the arbitrary and capricious whims of others makes you feel a sense of helplessness, which is extremely stressful and grueling, and can eventually break a person mentally and emotionally, and is therefore a favored tactic used by tyrants to break the will of the population so that they are too broken to revolt (see Stalin’s reign of terror).
Invalidating Your Personal Identity
Masking is now – regardless of the factual merits – a political symbol in society. Being forced to mask is by definition being forced to yield in ones own actions – and worse, in ones public appearance – to your ideological and/or political opposition. Imagine if the government decided to make wearing a religious skullcap mandatory for everyone – you can make the same argument that is being made for masking – what’s the big deal, you barely notice it, etc – I am quite confident that atheists for instance would would feel very keenly the assault on their personal identity.
Deprives / Ruins Human Interactions
The quality and nature of social interactions is greatly reduced. Every interaction behind masks is fundamentally different. Interacting in this way can feel sad, despondent, isolating, cold, and/or cruel, among other things.
Over Time Changes Your Personality
Facemasks are a radical and unnatural impingement on normal mental and emotional functioning. Over time, this can change your personality – such as making you less social, less outgoing, more suspicious, decreased tendency or desire to be kind and so on.
A General Feeling of Being Trapped in a Nightmare
Many people feel a clear and distinct sense of being trapped in some sort of perverse nightmare as a result of covid policies, which is an extremely distressing experience, especially when there feels like there is no end in sight.
Elementary Lack of Fairness
People are very sensitive to fairness, and can feel enormous stress and distress when treated unfairly, especially when the unfair treatment is egregious. Mask policies are literally imposing on some people so other people can feel safer – a grotesquely unequal treatment, that in order to help the emotional health of the scared-to-death-of-covid pro-maskers, everyone else’s mental & emotional health will be trampled on by forced masking. Moreover, mask mandates preferentially enshrines the political, moral, and ideological views and sensibilities of one segment of society without any justification.
The Stress of Difficulty Communicating
The frustration that comes from difficulty communicating is underappreciated, and tends to leave people feeling annoyed, frustrated and stressed.
The Damage From Failed Communication
This particular harm also has another, more tangible dimension – often, people having a hard time communicating simply give up, and giving up is itself an added stress factor that leaves people frazzled. If you’re talking to your doctor and you “give up” instead of making sure you understood what he was trying to tell you – especially older people who psychologically tend to both give up faster and have more innate difficulty physically hearing to begin with – that could be a big problem.
Dehumanization Through Forced Anonymity
The face is the most visibly manifest characteristic that sets you apart as a unique individual. Masks, by covering your face, strip you to some degree of your sense of being a unique individual and instead makes you feel more like a number than a person. It also distorts your sense of the humanity of others, as you inevitably become trained to perceive other people as lacking human-ness.
They’re so Darn Uncomfortable
Masks can be extremely uncomfortable to wear, especially for long stretches at a time. They can also be quite gross to wear – if you sneeze into the mask, well……
An Evidence Based Scientific Analysis of Why Masks are Ineffective, Unnecessary, and Harmful
20 de noviembre de 2020 About Dr. Meehan Jim Meehan, MD is an ophthalmologist and preventive medicine specialist with over 20 years of experience and advanced training in immunology, inflammation, and infectious disease. He has performed well over 10,000 surgical procedures. His research experience includes investigating associations between military vaccinations and Gulf War Syndrome. Dr. Meehan is also trained in internal medicine, addiction medicine, endocrinology, integrative medicine, functional medicine, and nutrition.
Dr. Meehan is a former editor of the medical journal, “Ocular Immunology and Inflammation.” Dr. Meehan has peer-reviewed thousands of medical research studies. With this experience and expertise, Dr. Meehan has dedicated his career to protecting his patients and the public from the fraud, corruption, and pseudoscience so often used by agents and agencies whose motives and interests have resulted in American medicine and pharmaceutical drugs becoming the third leading cause of death in the United States
[Recent studies] found that about a third of the [healthcare] workers developed headaches with use of the mask, most had preexisting headaches that were worsened by the mask wearing, and 60% required pain medications for relief. As to the cause of the headaches, while straps and pressure from the mask could be causative, the bulk of the evidence points toward hypoxia and/or hypercapnia as the cause. That is, a reduction in blood oxygenation (hypoxia) or an elevation in blood C02 (hypercapnia).
It is known that the N95 mask, if worn for hours, can reduce blood oxygenation as much as 20%, which can lead to a loss of consciousness.
The importance of these findings is that a drop in oxygen levels (hypoxia) is associated with an impairment in immunity. Studies have shown that hypoxia can inhibit the type of main immune cells used to fight viral infections called the CD4+ T-lymphocyte.
This occurs because the hypoxia increases the level of a compound called hypoxia inducible factor-1 (HIF-1), which inhibits T-lymphocytes and stimulates a powerful immune inhibitor cell called the Tregs.
This sets the stage for contracting any infection, including COVID-19 and making the consequences of that infection much graver. In essence, your mask may very well put you at an increased risk of infections and if so, having a much worse outcome.
- See also Denis G. Rancourt, PhD, Masks Don’t Work: A review of science relevant to COVID-19 social policy, Ontario Civil Liberties Association, April 11, 2020. https://www.researchgate.net/publication/340570735
Coronavirus: Face masks could increase risk of infection, medical chief warns
‘For the average member of the public walking down a street, it is not a good idea’ Chris Baynes Thursday 12 March 2020 13:50 Members of the public could be putting themselves more at risk from contracting coronavirus by wearing face masks, one of England’s most senior doctors has warned. Jenny Harries, deputy chief medical officer, said the masks could “actually trap the virus” and cause the person wearing it to breathe it in. https://www.independent.co.uk/news/health/coronavirus-news-face-masks-increase-risk-infection-doctor-jenny-harries-a9396811.html
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